Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition

• Published in: Brain Structure and Function Vol. 229; no. 5; pp. 1047 - 1072
• Main Authors: Basile, Gianpaolo Antonio, Tatti, Elisa, Bertino, Salvatore, Milardi, Demetrio, Genovese, Giovanni, Bruno, Antonio, Muscatello, Maria Rosaria Anna, Ciurleo, Rosella, Cerasa, Antonio, Quartarone, Angelo, Cacciola, Alberto
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2024; Springer Nature B.V
• Subjects: Animal models; Animals; Biomedical and Life Sciences; Biomedicine; Brain - anatomy & histology; Brain - diagnostic imaging; Brain - physiology; Brain architecture; Brain Mapping; Brain research; Cell Biology; Cognition & reasoning; Emotions - physiology; Humans; Mental disorders; Neural Pathways - anatomy & histology; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Neuroimaging; Neurology; Neurosciences; Personal Space; Review; Social Cognition; Social interactions; Space Perception - physiology; Neuroimaging; Function; Networks; Anatomy; Neuropsychiatry; Attention
• ISSN: 1863-2661; 1863-2653; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-024-02781-9

Peripersonal space (PPS) is a construct referring to the portion of space immediately surrounding our bodies, where most of the interactions between the subject and the environment, including other individuals, take place. Decades of animal and human neuroscience research have revealed that the brain holds a separate representation of this region of space: this distinct spatial representation has evolved to ensure proper relevance to stimuli that are close to the body and prompt an appropriate behavioral response. The neural underpinnings of such construct have been thoroughly investigated by different generations of studies involving anatomical and electrophysiological investigations in animal models, and, recently, neuroimaging experiments in human subjects. Here, we provide a comprehensive anatomical overview of the anatomical circuitry underlying PPS representation in the human brain. Gathering evidence from multiple areas of research, we identified cortical and subcortical regions that are involved in specific aspects of PPS encoding. We show how these regions are part of segregated, yet integrated functional networks within the brain, which are in turn involved in higher-order integration of information. This wide-scale circuitry accounts for the relevance of PPS encoding in multiple brain functions, including not only motor planning and visuospatial attention but also emotional and social cognitive aspects. A complete characterization of these circuits may clarify the derangements of PPS representation observed in different neurological and neuropsychiatric diseases.