Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis

The diversity in growth and morphological characteristics among endothelial cells in different normal tissues and tumors has been long recognized. Yet there has been no clear molecular explanation for such diversity at the level of vascular endothelial growth factor A (VEGF-A) and other established...

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Published inNature medicine Vol. 8; no. 9; pp. 913 - 917
Main Authors LeCouter, Jennifer, Lin, Rui, Ferrara, Napoleone
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.09.2002
Subjects
Angiogenesis
Animals
Cell growth
Endocrine Glands - metabolism
Endothelial Growth Factors - physiology
Endothelium
Gastrointestinal Hormones
Humans
Hypotheses
Ligands
Lymphokines - physiology
Mitogens - physiology
Neovascularization, Physiologic
Organ Specificity
Peptides
Physiology
Proteins
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
Vascular Endothelial Growth Factors
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Summary:The diversity in growth and morphological characteristics among endothelial cells in different normal tissues and tumors has been long recognized. Yet there has been no clear molecular explanation for such diversity at the level of vascular endothelial growth factor A (VEGF-A) and other established regulators of angiogenesis that are expressed widely and show little tissue selectivity in their angiogenic properties. Endocrine gland-derived VEGF represents the first example of a tissue-specific angiogenic factor, likely to be followed by others.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1078-8956
1546-170X
DOI:10.1038/nm0902-913