Efficacy of Twice a Day Bismuth Quadruple Therapy for Second-Line Treatment of Helicobacter pylori Infection

Bismuth quadruple therapy (BQT) is an effective treatment for infection. However, frequent dosing schedules of BQT regimen often compromise drug adherence and may affect treatment outcomes. This retrospective study aimed to investigate the efficacy of twice-daily BQT compared to that of four times a...

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Published inJournal of personalized medicine Vol. 12; no. 1; p. 56
Main Authors Kim, Jeemyoung, Gong, Eun Jeong, Seo, Myeongsook, Seo, Hyun Il, Park, Jong Kyu, Lee, Sang Jin, Han, Koon Hee, Jeong, Woo Jin, Kim, Young Don, Cheon, Gab Jin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.01.2022
MDPI
Subjects
Antibiotics
Antimicrobial agents
Dosage
drug administration schedule
Drug resistance
Eradication
Failure
Helicobacter pylori
Infections
Metronidazole
Multivariate analysis
Patients
Precision medicine
Proton pump inhibitors
treatment outcome
Ulcers
Helicobacter pylori
treatment outcome
drug administration schedule
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Summary:Bismuth quadruple therapy (BQT) is an effective treatment for infection. However, frequent dosing schedules of BQT regimen often compromise drug adherence and may affect treatment outcomes. This retrospective study aimed to investigate the efficacy of twice-daily BQT compared to that of four times a day therapy. From August 2018 to November 2020, adult patients who failed first-line standard triple therapy and underwent BQT were eligible. Patients were categorized into two groups according to dosing schedule: (i) the BQT group ( = 213) who received standard BQT administered four times a day; and (ii) the BQTb group ( = 141) who received proton pump inhibitor, bismuth 600 mg, metronidazole 500 mg, and tetracycline 1 g twice a day. The eradication rate did not differ between the BQT (92.5%) and the BQTb groups (90.1%) ( = 0.441). Adherence and adverse event rate were similar between the two groups. Multivariate analysis showed that current smoking was associated with eradication failure; however, dosing frequency was not associated with the efficacy of eradication therapy. This study suggested that twice a day BQT is as effective as four times a day therapy for second-line treatment of infection.
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ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12010056