Linking specific biological signatures to different childhood adversities: findings from the HERO project

• Published in: Pediatric research Vol. 94; no. 2; pp. 564 - 574
• Main Authors: de Mendonça Filho, Euclides José, Pokhvisneva, Irina, Maalouf, Christina Maria, Parent, Carine, Mliner, Shanna B., Slopen, Natalie, Williams, David R., Bush, Nicole R., Boyce, William Thomas, Levitt, Pat, Nelson, Charles A., Gunnar, Megan R., Meaney, Michael J., Shonkoff, Jack P., Silveira, Patricia Pelufo
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2023; Nature Publishing Group
• Subjects: Child; Clinical; Clinical Research Article; Cortisone; Dehydroepiandrosterone; Hormones; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Medicine; Medicine & Public Health; Pediatric Surgery; Pediatrics; Pituitary-Adrenal System; Saliva; Stress, Psychological; Tumor Necrosis Factor-alpha
• ISSN: 0031-3998; 1530-0447; 1530-0447
• DOI: 10.1038/s41390-022-02415-y

Background Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited. Methods Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children ( N  = 142; N  = 145). Results Children exposed to higher SES-D had higher levels of TNF-α ( B  = 0.13, p  = 0.011), IL-1β ( B  = 0.10, p  = 0.033), and DHEA ( B  = 0.16, p  = 0.011). Higher family dysfunction was associated with higher cortisol ( B  = 0.08, p  = 0.033) and cortisone ( B  = 0.05, p  = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels ( p  = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample. Conclusions Our results indicate that these biological response systems may react differently to different forms of early-life adversity. Impact Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking. Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA. Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage. Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities.