Adventitial Cuffs: Regional Hubs for Tissue Immunity

Inflammation must be effective, while limiting excessive tissue damage. To walk this line, immune functions are grossly compartmentalized by innate cells that act locally and adaptive cells that function systemically. But what about the myriad tissue-resident immune cells that are critical to this b...

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Bibliographic Details
Published inTrends in immunology Vol. 40; no. 10; pp. 877 - 887
Main Authors Dahlgren, Madelene W., Molofsky, Ari B.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2019
Elsevier Limited
Subjects
Adaptive immunity
Allergies
Asthma
Cardiovascular disease
Crosstalk
Cuffs
Dendritic cells
Diabetes
Immune system
Infections
Inflammation
innate lymphoid cells
Laboratories
Lymphatic system
Lymphocytes
Metabolism
Nerves
Organs
perivascular niche
Smooth muscle
Stromal cells
tissue immunity
Tissues
Tumor necrosis factor-TNF
perivascular niche
innate lymphoid cells
stromal cells
tissue immunity
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Summary:Inflammation must be effective, while limiting excessive tissue damage. To walk this line, immune functions are grossly compartmentalized by innate cells that act locally and adaptive cells that function systemically. But what about the myriad tissue-resident immune cells that are critical to this balancing act and lie on a spectrum of innate and adaptive immunity? We propose that mammalian perivascular adventitial ‘cuffs’ are conserved sites in multiple organs, enriched for these tissue-resident lymphocytes and dendritic cells, as well as lymphatics, nerves, and subsets of specialized stromal cells. Here, we argue that these boundary sites integrate diverse tissue signals to regulate the movement of immune cells and interstitial fluid, facilitate immune crosstalk, and ultimately act to coordinate regional tissue immunity. Perivascular, mammalian adventitial cuffs are enriched in specialized stromal cells and tissue-resident immune cells, acting as outposts for regional tissue immunity.Adventitial cuffs are dynamic environments that channel interstitial fluid from tissue parenchyma to lymphatics.Stromal cells are heterogenous and shape discrete functional niches in tissues.Stromal cell subset(s) can support the differentiation and maintenance of innate lymphocytes in peripheral tissues.
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ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2019.08.002