Supramolecular approaches to mediate chemical reactivity

• Published in: Beilstein journal of organic chemistry Vol. 18; no. 1; pp. 1463 - 1465
• Main Authors: Ballester, Pablo, Wang, Qi-Qiang, Gaeta, Carmine
• Format: Journal Article
• Language: English
• Published: Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 2022; Beilstein-Institut
• Subjects: Catalysis; Catalysts; Chemistry; Enzymes; Intermediates; Photocatalysis; Stereoselectivity
• ISSN: 1860-5397; 2195-951X; 1860-5397
• DOI: 10.3762/bjoc.18.152

[...]molecular recognition of the substrate(s ) and potentially the transition state is essential in supramolecular catalysis. If reactants are confined in the restricted space provided by an enzyme binding pocket, the increase in local concentration, due to the proximity effect, the stabilization of intermediates and transition states cause the acceleration of the reaction. [...]learning from natural enzymes, novel supramolecular catalysts were designed that showed substrate selectivity, turnover, regioselectivity, and stereoselectivity [5-14], Supramolecular architectures with an internal cavity are potential candidates to work as supramolecular catalysts [5-14]. [...]the classical rules of organic reactivity are often violated [6,11]. [...]party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.