Relationships among nutritional status and skeletal and respiratory muscle function in cystic fibrosis: does early dietary supplementation make a difference?

• Published in: The American journal of clinical nutrition Vol. 57; no. 4; pp. 580 - 587
• Main Authors: Hanning, RM, Blimkie, C J R, Bar-Or, O, Lands, LC, Moss, LA, Wilson, WM
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.04.1993; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: ACTIVIDAD FISICA; ACTIVITE PHYSIQUE; Adolescent; Anthropometry; Biological and medical sciences; blood plasma; blood proteins; Body Composition; body weight; Child; Children & youth; COMPLEMENTATION; Cystic fibrosis; Cystic Fibrosis - physiopathology; dietary supplements; ENERGIA; ENERGIE; Energy Intake; ENFANT; ENFERMEDADES RESPIRATORIAS; ENRIQUECIMIENTO DE LOS ALIMENTOS; ESTADO NUTRICIONAL; ETAT NUTRITIONNEL; Exercise; Exercise - physiology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Lungs; MALADIE RESPIRATOIRE; Medical research; Medical sciences; MUSCLE; muscles; Muscles - physiopathology; MUSCULOS; NINOS; NUTRICION HUMANA; Nutrition; NUTRITION HUMAINE; nutritional assessment; nutritional intervention; nutritional status; Nutritional Status - physiology; ONTARIO; Other diseases. Semiology; PESO; physical activity; physiology; physiopathology; PLASMA SANGUIN; PLASMA SANGUINEO; POIDS; Prospective Studies; protein; PROTEINAS SANGUINEAS; PROTEINE SANGUINE; RESISTANCE MECANIQUE; RESISTENCIA MECANICA; RESPIRACION; RESPIRATION; Respiratory Function Tests; Respiratory Muscles; Respiratory Muscles - physiopathology; respiratory system; school children; SISTEMA RESPIRATORIO; skeletal muscle; Skeletal system; SYSTEME RESPIRATOIRE; Ontario; Cystic fibrosis; nutritional assessment; protein; Human; Respiratory disease; Growth; Supplemented diet; Striated muscle; Congenital disease; Mucoviscidosis; Diet therapy; Nitrogen balance; Respiratory muscle; Digestive diseases; Child; Nutritional status; Pancreatic disease
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/57.4.580

Relationships among nutritional status and skeletal and respiratory muscle function were examined in 16 children with cystic fibrosis (CF) and mild lung disease (FEV1 95 ± 16% predicted). Subjects were randomly assigned to receive (or not) noninvasive nutritional supplementation at 25% of normal energy recommendations for 6 mo. Skeletal muscle strength and power were similar to those of healthy children as were respiratory muscle strength and endurance. Stepwise-regression analysis indicated that changes in skeletal muscle strength and energy intake correlated significantly with growth [weight (kg) = 1.90 − 0.60 (Tanner Stage) + 0.49 (maximum voluntary strength (Nm) + 0.03 (energy intake, % RNI), r = 0.76, P< 0.05], though body composition, protein biochemistry, muscle power, respiratory muscle strength, and use of dietary supplements did not. Thus, changes in skeletal muscle strength may be a functional index of changes in nutritional status in CF. Dietary supplementation per se was not associated with functional improvement.