Microfabricated drug delivery systems: from particles to pores

Microfabrication techniques which permit the creation of therapeutic delivery systems that possess a combination of structural, mechanical, and perhaps electronic features may surmount challenges associated with conventional delivery of therapy. In this review, delivery concepts are presented which...

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Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 55; no. 3; pp. 315 - 328
Main Authors Tao, Sarah L, Desai, Tejal A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 24.02.2003
Subjects
Absorbable Implants - trends
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - chemical synthesis
Drug delivery
Drug Delivery Systems - methods
Drug Delivery Systems - trends
Microchemistry - methods
Microchemistry - trends
Microfabrication
Microparticles
Microspheres
Microtechnology
Silicon
Therapeutic
Therapeutic
Silicon
Drug delivery
Microfabrication
Microtechnology
Microparticles
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Summary:Microfabrication techniques which permit the creation of therapeutic delivery systems that possess a combination of structural, mechanical, and perhaps electronic features may surmount challenges associated with conventional delivery of therapy. In this review, delivery concepts are presented which capitalize on the strengths of microfabrication. Possible applications include micromachined silicon membranes to create implantable biocapsules for the immunoisolation of pancreatic islet cells—as a possible treatment for diabetes—and sustained release of injectable drugs needed over long time periods. Asymmetrical, drug-loaded microfabricated particles with specific ligands linked to the surface are proposed for improving oral bioavailability of peptide (and perhaps protein) drugs. In addition, microfabricated drug delivery systems ranging from transdermal microneedles to implantable microchips will be discussed.
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ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(02)00227-2