Emergence of influenza A (H1N1)pdm09 genogroup 6B and drug resistant virus, India, January to May 2015

• Published in: Euro surveillance : bulletin européen sur les maladies transmissibles Vol. 21; no. 5; pp. 6 - 11
• Main Authors: Parida, Manmohan, Dash, Paban Kumar, Kumar, Jyoti S, Joshi, Gaurav, Tandel, Kundan, Sharma, Shashi, Srivastava, Ambuj, Agarwal, Ankita, Saha, Amrita, Saraswat, Shweta, Karothia, Divyanshi, Malviya, Vatsala
• Format: Journal Article
• Language: English
• Published: Sweden Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) 04.02.2016
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents - therapeutic use; Child; Child, Preschool; Disease Outbreaks; Drug resistance; Epidemics; Genes; Genotype; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Humans; India - epidemiology; Infant; Infant, Newborn; Influenza; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - isolation & purification; Influenza, Human - diagnosis; Influenza, Human - epidemiology; Influenza, Human - virology; Middle Aged; Molecular Sequence Data; Mutation; Nasopharynx - virology; Neuraminidase - genetics; Oseltamivir - therapeutic use; Phylogenetics; Phylogeny; Population Surveillance; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Young Adult; India; phylogeny; drug resistance; pandemic; Swine Flu; H1N1; genogroup
• ISSN: 1560-7917; 1025-496X; 1560-7917
• DOI: 10.2807/1560-7917.ES.2016.21.5.30124

To investigate the aetiology of the 2015 A(H1N1)pdm09 influenza outbreak in India, 1,083 nasopharyngeal swabs from suspect patients were screened for influenza A(H1N1)pdm09 in the state of Madhya Pradesh. Of 412 positive specimens, six were further characterised by phylogenetic analysis of haemagglutinin (HA) sequences revealing that they belonged to genogroup 6B. A new mutation (E164G) was observed in HA2 of two sequences. Neuraminidase genes in two of 12 isolates from fatal cases on prior oseltamivir treatment harboured the H275Y mutation.