Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex

• Published in: Journal of assisted reproduction and genetics Vol. 40; no. 10; pp. 2385 - 2390
• Main Authors: Dunlop, CE, Jack, SA, Telfer, EE, Zahra, S., Anderson, RA
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2023; Springer Nature B.V
• Subjects: Biopsy; Case reports; Cryopreservation; Fertility; Fertility Preservation; Genetic disorders; Genetics; Gynecology; Human Genetics; Implantation; Infertility; Laparoscopy; Medicine; Medicine & Public Health; Menstruation; Miscarriage; Ovaries; Patients; Phenotypes; Pregnancy; Puberty; Reproductive health; Reproductive Medicine; Turner's syndrome; Ultrasonic imaging; Uterus; Womens health; X chromosomes; Ovarian cortex re-implantation; Fertility preservation; Premature ovarian insufficiency; Turner syndrome
• ISSN: 1058-0468; 1573-7330; 1573-7330
• DOI: 10.1007/s10815-023-02905-w

Turner syndrome (TS) leads to a characteristic phenotype, including premature ovarian insufficiency and infertility. Ovarian tissue cryopreservation (OTC) is becoming an established fertility preservation strategy for both pre- and post-pubertal females and may offer the chance of having a biological family to selected patients with TS. To date, women with TS have had ovarian tissue cryopreserved but there are few reports of autologous re-implantation and none of pregnancy. We herein report, to our knowledge, the first clinical pregnancy in a patient with TS, conceived naturally following re-implantation of cryopreserved ovarian tissue which had been removed soon after spontaneous puberty. This provides proof of concept for OTC as a means of fertility preservation in TS.