Effects of Nystatin oral rinse on oral Candida species and Streptococcus mutans among healthy adults
Objectives To examine the effect of Nystatin oral rinse on oral Candida species and Streptococcus mutans carriage. Materials and methods Twenty healthy adults with oral candidiasis participated in the single-arm clinical trial and received Nystatin oral rinse for 7 days, 4 applications/day, and 600,...
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Published in | Clinical oral investigations Vol. 27; no. 7; pp. 3557 - 3568 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.07.2023
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Objectives
To examine the effect of Nystatin oral rinse on oral
Candida species
and
Streptococcus mutans
carriage.
Materials and methods
Twenty healthy adults with oral candidiasis participated in the single-arm clinical trial and received Nystatin oral rinse for 7 days, 4 applications/day, and 600,000 International Units/application. Demographic-socioeconomic-oral-medical conditions were obtained. Salivary and plaque
Candida species
and
Streptococcus mutans
were assessed at baseline and 1-week and 3-month follow-ups. Twenty-four salivary cytokines were assessed.
Candida albicans
isolates underwent Nystatin susceptibility test.
Results
Half of participants (10/20) were free of salivary
C. albicans
after using Nystatin rinse. Salivary
S. mutans
was significantly reduced at 3-month follow-up (
p
< 0.05). Periodontal status reflected by bleeding-on-probing was significantly improved at 1-week and 3-month follow-ups (
p
< 0.05). Plaque accumulation was significantly reduced at 1-week follow-up (
p
< 0.05). Interestingly, the responses to Nystatin oral rinse were not associated with race, gender, age, oral hygiene practice, adherence to Nystatin rinse, or sweet consumption (
p
> 0.05). No
C. albicans
isolates were resistant to Nystatin. Furthermore, salivary cytokine eotaxin and fractalkine were significantly reduced at 3-month follow-up among participants who responded to Nystatin rinse (
p
< 0.05).
Conclusions
The study results indicate that oral antifungal treatment had an effect on
S. mutans
salivary carriage. Future clinical trials are warranted to comprehensively assess the impact of antifungal treatment on the oral flora other than
S. mutans
and
Candida
.
Clinical relevance
Due to the potential cariogenic role of oral
Candida
species, antifungal approaches shed new light on the prevention and management of dental caries from a fungal perspective. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1436-3771 1432-6981 1436-3771 |
DOI: | 10.1007/s00784-023-04969-5 |