Elaborating polarity: PAR proteins and the cytoskeleton

Cell polarity is essential for cells to divide asymmetrically, form spatially restricted subcellular structures and participate in three-dimensional multicellular organization. PAR proteins are conserved polarity regulators that function by generating cortical landmarks that establish dynamic asymme...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 138; no. 5; pp. 799 - 809
Main Authors Nance, Jeremy, Zallen, Jennifer A
Format Journal Article
LanguageEnglish
Published England Company of Biologists 01.03.2011
Subjects
Animals
Caenorhabditis elegans
Cell Polarity
Cytoskeletal Proteins - physiology
Cytoskeleton - physiology
Drosophila
Receptors, Proteinase-Activated - metabolism
Receptors, Proteinase-Activated - physiology
Review
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Summary:Cell polarity is essential for cells to divide asymmetrically, form spatially restricted subcellular structures and participate in three-dimensional multicellular organization. PAR proteins are conserved polarity regulators that function by generating cortical landmarks that establish dynamic asymmetries in the distribution of effector proteins. Here, we review recent findings on the role of PAR proteins in cell polarity in C. elegans and Drosophila, and emphasize the links that exist between PAR networks and cytoskeletal proteins that both regulate PAR protein localization and act as downstream effectors to elaborate polarity within the cell.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.053538