Comparison of Propofol or Isoflurane Anesthesia Maintenance, Combined with a Fentanyl-Lidocaine-Ketamine Constant-Rate Infusion in Goats Undergoing Abomasotomy

• Published in: Animals (Basel) Vol. 11; no. 2; p. 492
• Main Authors: Velázquez-Delgado, Perla I, Gutierrez-Blanco, Eduardo, Torres-Acosta, Felipe de J, Ortega-Pacheco, Antonio, Aguilar-Caballero, Armando J, Dzikiti, Brighton T
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.02.2021; MDPI
• Subjects: Analgesics; Anesthesia; Anesthetics; Blood pressure; Catheters; Drug dosages; Fentanyl; General anesthesia; goat; Goats; Hemoglobin; Infusion pumps; Intravenous administration; Intubation; Isoflurane; Ketamine; Lidocaine; Maintenance; Oxygen saturation; partial intravenous anesthesia; Pollution effects; Propofol; Surgery; total intravenous anesthesia; Veins & arteries; Brazil; Mexico; United States > US; China; goat; isoflurane; total intravenous anesthesia; propofol; partial intravenous anesthesia; anesthesia
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani11020492

This study aimed to compare, first, the anesthetic and cardiopulmonary effects of propofol or isoflurane anesthetic maintenance in goats receiving a fentanyl-lidocaine-ketamine infusion undergoing abomasotomy and, secondly, to compare the quality of the recovery from anesthesia. Two groups were used: propofol (TIVA) and isoflurane (PIVA). Goats were premedicated with fentanyl (10 μg/kg intravenously [IV]), lidocaine (2 mg/kg, IV), and ketamine (1.5 mg/kg, IV). Anesthesia was induced with propofol and maintenance consisted of fentanyl (10 μg/kg/h, IV), lidocaine (50 μg/kg/min, IV), and ketamine (50 μg/kg/min, IV) as constant-rate infusions (CRIs), combined with either CRI of propofol at initial dose of 0.3 mg/kg/min, IV (TIVA), or isoflurane with initial end-tidal (FE'Iso) concentration of 1.2% partial intravenous anesthesia (PIVA). The mean effective propofol dose for maintenance was 0.44 ± 0.07 mg/kg/min, while the mean FE'Iso was 0.81 ± 0.2%. Higher systolic arterial pressure (SAP) values were observed in total intravenous anesthesia (TIVA) during some time points. Recovery was smooth in PIVA, while restlessness, vocalizations, and paddling were observed in TIVA. Both protocols produced a satisfactory quality of anesthesia during surgery, with minimal impact on cardiopulmonary function. Nevertheless, recovery after anesthesia in TIVA might be of poor quality.