The mechanisms of pathological extramedullary hematopoiesis in diseases

• Published in: Cellular and molecular life sciences : CMLS Vol. 77; no. 14; pp. 2723 - 2738
• Main Authors: Yang, Xinxin, Chen, Degao, Long, Haixia, Zhu, Bo
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2020; Springer Nature B.V
• Subjects: Activation; Anemia; Atherosclerosis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bone marrow; Cell Biology; Cells (biology); Embryonic Stem Cells; Embryos; Hematopoiesis; Hematopoiesis, Extramedullary - genetics; Hematopoietic Stem Cells; Humans; Immune system; Immunosuppression; Immunosuppression Therapy; Life Sciences; Molecular modelling; Neoplasms - genetics; Neoplasms - pathology; Organs; Osteoprogenitor cells; Progenitor cells; Review; Stress, Physiological - genetics; Supplements; Tumors; Erythropoiesis; Niche; Thalassemia; Inflammation; Myelofibrosis; Atherosclerosis
• ISSN: 1420-682X; 1420-9071
• DOI: 10.1007/s00018-020-03450-w

Extramedullary hematopoiesis (EMH) is the expansion and differentiation of hematopoietic stem and progenitor cells outside of the bone marrow. In postnatal life, as a compensatory mechanism for ineffective hematopoiesis of the bone marrow, pathological EMH is triggered by hematopoietic disorders, insufficient hematopoietic compensation, and other pathological stress conditions, such as infection, advanced tumors, anemia, and metabolic stress. Pathological EMH has been reported in many organs, and the sites of pathological EMH may be related to reactivation of the embryonic hematopoietic structure in these organs. As a double-edged sword (blood and immune cell supplementation as well as clinical complications), pathological EMH has been widely studied in recent years. In particular, pathological EMH induced by late-stage tumors contributes to tumor immunosuppression. Thus, a deeper understanding of the mechanism of pathological EMH may be conducive to the development of therapies against the pathological processes that induce EMH. This article reviews the recent progress of research on the cellular and molecular mechanisms of pathological EMH in specific diseases.