Association of p53 polymorphisms and colorectal cancer: Modulation of risk and progression

Abstract Objectives p53 Gene variants BstUI RFLP at codon 72 in exon 4, 16 bp tandem repeat in intron 3 and MspI RFLP in intron 6, which code for two functionally different protein isoforms, have been shown to modulate susceptibility to different types of human neoplasms. Methods p53 genotype was as...

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Published inEuropean journal of surgical oncology Vol. 35; no. 4; pp. 415 - 419
Main Authors Mammano, E, Belluco, C, Bonafé, M, Olivieri, F, Mugianesi, E, Barbi, C, Mishto, M, Cosci, M, Franceschi, C, Lise, M, Nitti, D
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2009
Subjects
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Cancer risk
Case-Control Studies
Centenarians
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Disease Progression
Female
Gene Frequency
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Odds Ratio
p53
Polymorphism
Polymorphism, Genetic
Risk Assessment
Surgery
Tumor Suppressor Protein p53 - genetics
Centenarians
Colorectal cancer
Cancer risk
p53
Polymorphism
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Summary:Abstract Objectives p53 Gene variants BstUI RFLP at codon 72 in exon 4, 16 bp tandem repeat in intron 3 and MspI RFLP in intron 6, which code for two functionally different protein isoforms, have been shown to modulate susceptibility to different types of human neoplasms. Methods p53 genotype was assessed in 90 CRC patients, 321 age-matched controls and 322 centenarians. Results The p53 codon 72 arginine, the p53 16 bp deletion, and the MspI RFLP were significantly more frequent in CRC patients in comparison to the controls and to the centenarians (odd ratio 1.44 and 1.93). In the CRC group, the BstUI RFLP polymorphism was the more frequent combination (62.2%), and it was significantly associated with highly infiltrating ( p < 0.01), poorly differentiated ( p < 0.01), and metastatic ( p < 0.05) tumours. Our findings indicate that the p53 codon 72 polymorphisms are associated with a higher risk of CRC and are associated with more advanced and undifferentiated tumours.
Bibliography:ObjectType-Article-1
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ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2008.03.003