Synthesis of (+)-(R)-1-amino-2,2-difluorocyclopropane-1-carboxylic acid through lipase-catalyzed asymmetric acetylation

(+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.

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Bibliographic Details
Published inChemistry letters no. 5; pp. 405 - 406
Main Authors Kirihara, M, Takuwa, T, Kawasaki, M, Kakuda, H, Hirokami, S, Takahata, H
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 01.05.1999
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
GLYCINE
1-AMINOCYCLOPROPANE CARBOXYLIC-ACID
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Summary:(+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1999.405