Glyphosate and Aminomethylphosphonic Acid (AMPA) Modulate Glutathione S-Transferase in Non-Tumorigenic Prostate Cells

• Published in: International journal of molecular sciences Vol. 24; no. 7; p. 6323
• Main Authors: Borges, Dayanne Silva, Vecchi, Lara, Barros, Deysse Carla Tolentino, Arruda, Vinícius Marques, Ferreira, Helen Soares Valença, da Silva, Matheus Fernandes, Guerra, Joyce Ferreira da Costa, Siqueira, Raoni Pais, Araújo, Thaise Gonçalves
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.03.2023; MDPI
• Subjects: Agricultural production; Agriculture; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; aminomethylphosphonic acid; Cancer; Cell lines; Cell proliferation; Cell viability; Coffee industry; Cytotoxicity; Enzymes; Gene expression; Glutathione Transferase; Glycine; Glyphosate; Herbicides; Herbicides - metabolism; Herbicides - pharmacology; Humans; Low concentrations; Male; Metabolism; Metabolites; Microorganisms; mRNA; organophosphate; Oxidative stress; Pesticides; Prostate; Prostate - metabolism; Proteins; Scientific equipment and supplies industry; Tetrazoles - pharmacology; Thiols; Brazil; United States; Massachusetts; organophosphate; metabolism; prostate; transcripts; aminomethylphosphonic acid; glyphosate

Glyphosate (GLY) was developed in the early 1970s and has become the most used broad-spectrum herbicide in the world so far. Its main metabolite is aminomethylphosphonic acid (AMPA), and the accumulation of GLY and its derivative compounds raises some concerns regarding possible health outcomes. In...