DYT1 dystonia increases risk taking in humans

It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymm...

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Bibliographic Details
Published ineLife Vol. 5
Main Authors Arkadir, David, Radulescu, Angela, Raymond, Deborah, Lubarr, Naomi, Bressman, Susan B, Mazzoni, Pietro, Niv, Yael
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publications Ltd 01.06.2016
eLife Sciences Publications, Ltd
Subjects
Age
Animal models
Behavior
Behavioral plasticity
Cortex
Dopamine
Dystonia
Dystonia - genetics
Dystonia - psychology
Expected values
Humans
Long-term depression
Long-term potentiation
Molecular Chaperones - genetics
Neostriatum
Neuroscience
Point mutation
reinforcement learning
risk aversion
Risk-Taking
Short Report
Synaptic depression
risk aversion
human
dystonia
neuroscience
reinforcement learning
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Summary:It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.14155