Focus on the agents most frequently responsible for perioperative anaphylaxis

Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative...

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Published inClinical and molecular allergy CMA Vol. 16; no. 1; p. 16
Main Authors Di Leo, E, Delle Donne, P, Calogiuri, G F, Macchia, L, Nettis, E
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 09.07.2018
BioMed Central
BMC
Subjects
Allergies
Anaphylaxis
Anesthesia
Anesthesiology
Antibiotics
Complications and side effects
Drugs
Immunoglobulin E
Latex
Mortality
Neuromuscular blocking agents
Perioperative allergy
Review
Risk factors
Rubber products
Skin
France
Neuromuscular blocking agents
Perioperative allergy
Anaphylaxis
Latex
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Summary:Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). All these substances (i.e. NMBA, anesthetics, antibiotics, latex devices) may cause severe systemic non-IgE-mediated reactions or fatal anaphylactic events even in the absence of any evident risk factor in the patient's anamnesis. For this reason, in order to minimize perioperative anaphylactic reactions, it is important to have rapid, specific, sensitive in vitro diagnostic tests able to confirm the clinical diagnosis of acute anaphylaxis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1476-7961
1476-7961
DOI:10.1186/s12948-018-0094-7