Phytotherapeutics in cancer invasion and metastasis

• Published in: Phytotherapy research Vol. 32; no. 8; pp. 1425 - 1449
• Main Authors: Salehi, Bahare, Zucca, Paolo, Sharifi‐Rad, Mehdi, Pezzani, Raffaele, Rajabi, Sadegh, Setzer, William N., Varoni, Elena Maria, Iriti, Marcello, Kobarfard, Farzad, Sharifi‐Rad, Javad
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2018
• Subjects: adjuvant therapy; Adjuvants; Angiogenesis; Antiangiogenics; anticancer drugs; Anticancer properties; Antitumor agents; Cancer; cancer chemoprevention; Carcinogenesis; Carcinogens; chemotherapy; Drug discovery; Metastases; Metastasis; phytochemicals; plant products; cancer chemoprevention; adjuvant therapy; phytochemicals; anticancer drugs; chemotherapy; plant products
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.6087

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.