Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates

On the surface of it: Experimental and computational analyses for a hybrid peptide–substrate system showed that changing the position of a proline residue in synthetic peptides changes their adsorption onto semiconductors substantially and predictably (see picture with a Si(100) surface). Such infor...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 49; no. 49; pp. 9530 - 9533
Main Authors Bachmann, Michael, Goede, Karsten, Beck-Sickinger, Annette G, Grundmann, Marius, Irbäck, Anders, Janke, Wolfhard
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 03.12.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Adsorption
atomic force spectroscopy
Chemical Sciences
Computer Simulation
hybrid interfaces
Kemi
Models, Molecular
Monte Carlo simulations
Mutation
Natural Sciences
Naturvetenskap
Particle Size
peptide adsorption
Peptides - chemistry
Proline - chemistry
Proline - genetics
Semiconductors
Surface Properties
Online AccessGet full text

Cover

More Information
Summary:On the surface of it: Experimental and computational analyses for a hybrid peptide–substrate system showed that changing the position of a proline residue in synthetic peptides changes their adsorption onto semiconductors substantially and predictably (see picture with a Si(100) surface). Such information is essential for the formation of novel peptide–solid interfaces for nanotechnological applications.
Bibliography:http://dx.doi.org/10.1002/anie.201000984
German-French DFH-UFA PhD College - No. CDFA-02-07
We thank Simon Mitternacht for helpful discussions regarding the peptide model and C. Dammann for peptide synthesis and purification. M.B. thanks the DFG (German Science Foundation) and the Wenner-Gren Foundation (Sweden) for research fellowships, and the German-Israeli "Umbrella" program for support. M.B., A.I., and W.J. are grateful for support by the German-Swedish DAAD-STINT Personnel Exchange Programme. This work is also partially funded by the DFG under Grant No. JA 483/24-1/2/3, the Leipzig Graduate School of Excellence "BuildMoNa", TR 67A4, and the German-French DFH-UFA PhD College under Grant No. CDFA-02-07. Supercomputer time at the John von Neumann Institute for Computing (NIC), Forschungszentrum Jülich, is acknowledged (Grant Nos. hlz11, jiff39, and jiff43).
STINT
DFG - No. JA 483/24-1/2/3
Wenner-Gren Foundation
Leipzig Graduate School of Excellence "BuildMoNa" - No. TR 67A4
istex:83DA0AA2192195AEA60DB748AD30B68C9ED5D176
Forschungszentrum Jülich - No. hlz11; No. jiff39; No. jiff43
ark:/67375/WNG-HLLV9T4F-J
ArticleID:ANIE201000984
DAAD
We thank Simon Mitternacht for helpful discussions regarding the peptide model and C. Dammann for peptide synthesis and purification. M.B. thanks the DFG (German Science Foundation) and the Wenner‐Gren Foundation (Sweden) for research fellowships, and the German–Israeli “Umbrella” program for support. M.B., A.I., and W.J. are grateful for support by the German–Swedish DAAD–STINT Personnel Exchange Programme. This work is also partially funded by the DFG under Grant No. JA 483/24‐1/2/3, the Leipzig Graduate School of Excellence “BuildMoNa”, TR 67A4, and the German–French DFH‐UFA PhD College under Grant No. CDFA‐02‐07. Supercomputer time at the John von Neumann Institute for Computing (NIC), Forschungszentrum Jülich, is acknowledged (Grant Nos. hlz11, jiff39, and jiff43).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201000984