Effects of normobaric hyperoxia on haemodynamic parameters of healthy full‐term parturients

• Published in: Anaesthesia Vol. 62; no. 9; pp. 931 - 935
• Main Authors: Litchfield, K. N., Harten, J. M., Anderson, K. J., Kinsella, J., McGrady, E. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2007; Blackwell
• Subjects: Adult; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthesiology; Biological and medical sciences; Cardiac Output - physiology; Cardiography, Impedance; Cardiovascular system; Female; Heart Rate - physiology; Humans; Hypoxia; Measurement techniques; Medical sciences; Oxygen - blood; Oxygen Inhalation Therapy; Pregnancy; Pregnancy - physiology; Prenatal Care - methods; Vascular Resistance - physiology; Anesthesia; Hyperoxia
• ISSN: 0003-2409; 1365-2044
• DOI: 10.1111/j.1365-2044.2007.05150.x

Summary Fifteen healthy, full‐term women with singleton pregnancies were exposed to an increased FIo2 of 0.4 and their haemodynamic responses measured with a non‐invasive transthoracic bio‐impedance monitor. There was a mean reduction in cardiac index from 3.18 to 3.03 l.min−1.m−2 (4.7%, p = 0.004). The mean indexed systemic vascular resistance increased from 2049 to 2178 dynes.cm−5.m−2 (5.7%, p = 0.005). There were no significant changes in stroke index, heart rate or mean arterial pressure. This study demonstrates that even a moderate increase in inspired oxygen fraction has significant effects on the cardiovascular system of the term parturient.