Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following group...

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Published inBiological trace element research Vol. 201; no. 2; pp. 751 - 765
Main Authors Demir, Betul, Cicek, Demet, Orhan, Cemal, Er, Besir, Erten, Fusun, Tuzcu, Mehmet, Ozercan, Ibrahim Hanifi, Sahin, Nurhan, Komorowski, James, Ojalvo, Sara Perez, Sylla, Sarah, Sahin, Kazim
Format Journal Article
LanguageEnglish
Published New York Springer US 01.02.2023
Springer Nature B.V
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Abstract The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density ( p  < 0.05, p  < 0.01, and p  < 0.0001, respectively) and anagen ratio ( p  < 0.01, p  < 0.01, and p  < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased ( p  < 0.01, p  < 0.01, and p  < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI ( p  < 0.01, p  < 0.01, and p  < 0.05, respectively), ASI + MgB I ( p  < 0.0001 for all), and ASI + MgB II ( p  < 0.0001 for all) groups when compared to the control group. FGF-2 ( p  < 0.01) and IGF-1 ( p  < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI ( p  < 0.05 and p  < 0.01), ASI + MgB I ( p  < 0.001 for both), and ASI + MgB II ( p  < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I ( p  < 0.001) and ASI + MgB II ( p  < 0.0001) groups. In conclusion , the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin.
AbstractList The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density ( p  < 0.05, p  < 0.01, and p  < 0.0001, respectively) and anagen ratio ( p  < 0.01, p  < 0.01, and p  < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased ( p  < 0.01, p  < 0.01, and p  < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI ( p  < 0.01, p  < 0.01, and p  < 0.05, respectively), ASI + MgB I ( p  < 0.0001 for all), and ASI + MgB II ( p  < 0.0001 for all) groups when compared to the control group. FGF-2 ( p  < 0.01) and IGF-1 ( p  < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI ( p  < 0.05 and p  < 0.01), ASI + MgB I ( p  < 0.001 for both), and ASI + MgB II ( p  < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I ( p  < 0.001) and ASI + MgB II ( p  < 0.0001) groups. In conclusion , the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin.
The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague-Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density (p < 0.05, p < 0.01, and p < 0.0001, respectively) and anagen ratio (p < 0.01, p < 0.01, and p < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased (p < 0.01, p < 0.01, and p < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI (p < 0.01, p < 0.01, and p < 0.05, respectively), ASI + MgB I (p < 0.0001 for all), and ASI + MgB II (p < 0.0001 for all) groups when compared to the control group. FGF-2 (p < 0.01) and IGF-1 (p < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI (p < 0.05 and p < 0.01), ASI + MgB I (p < 0.001 for both), and ASI + MgB II (p < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I (p < 0.001) and ASI + MgB II (p < 0.0001) groups. In conclusion, the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin.
Abstract The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density (p < 0.05, p < 0.01, and p < 0.0001, respectively) and anagen ratio (p < 0.01, p < 0.01, and p < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased (p < 0.01, p < 0.01, and p < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI (p < 0.01, p < 0.01, and p < 0.05, respectively), ASI + MgB I (p < 0.0001 for all), and ASI + MgB II (p < 0.0001 for all) groups when compared to the control group. FGF-2 (p < 0.01) and IGF-1 (p < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI (p < 0.05 and p < 0.01), ASI + MgB I (p < 0.001 for both), and ASI + MgB II (p < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I (p < 0.001) and ASI + MgB II (p < 0.0001) groups. In conclusion, the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin.
Author Sahin, Kazim
Tuzcu, Mehmet
Ozercan, Ibrahim Hanifi
Sylla, Sarah
Sahin, Nurhan
Demir, Betul
Erten, Fusun
Komorowski, James
Orhan, Cemal
Cicek, Demet
Er, Besir
Ojalvo, Sara Perez
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crossref_primary_10_1111_srt_13800
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Issue 2
Keywords Hair
Nail
Biotin
Magnesium
Arginine silicate
Language English
License 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
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Snippet The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on...
Abstract The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate...
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proquest
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springer
SourceType Open Access Repository
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StartPage 751
SubjectTerms Animal models
Animals
Arginine
Arginine - pharmacology
beta Catenin
Biochemistry
Biomedical and Life Sciences
Biotechnology
Biotin
Blood pressure
Dermatitis
Diet
Female
Fibroblast growth factor 2
Glucose
Hair
Inositol
Inositol - pharmacology
Inositols
Insulin-Like Growth Factor I
Insulin-like growth factors
Laboratory animals
Life Sciences
Magnesium
Magnesium compounds
Metabolism
Nutrition
Oncology
Rats
Rats, Sprague-Dawley
Rodentia
Rodents
Silicates
Silicates - pharmacology
Skin
Tumor necrosis factor-TNF
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vitamin B complex
Wnt protein
β-Catenin
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Title Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model
URI https://link.springer.com/article/10.1007/s12011-022-03176-9
https://www.ncbi.nlm.nih.gov/pubmed/35226275
https://www.proquest.com/docview/2771378927
https://search.proquest.com/docview/2634545440
https://pubmed.ncbi.nlm.nih.gov/PMC8883010
Volume 201
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