The spread of antibiotic resistance to humans and potential protection strategies

• Published in: Ecotoxicology and environmental safety Vol. 254; p. 114734
• Main Authors: Ding, Dong, Wang, Bin, Zhang, Xiaoan, Zhang, Junxi, Zhang, Huanhuan, Liu, Xinxin, Gao, Zhan, Yu, Zengli
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.04.2023
• Subjects: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Bacterial Agents - pharmacology; Antibiotic consumption; Antibiotic resistance bacteria; Antibiotic resistance gene; Bacteria - genetics; Colonization resistance; Drug Resistance, Bacterial - genetics; Drug Resistance, Microbial - genetics; Genes, Bacterial; Humans; Colonization resistance; Antibiotic consumption; Antibiotic resistance gene; Antibiotic resistance bacteria
• ISSN: 0147-6513; 1090-2414; 1090-2414
• DOI: 10.1016/j.ecoenv.2023.114734

Antibiotic resistance is currently one of the greatest threats to human health. Widespread use and residues of antibiotics in humans, animals, and the environment can exert selective pressure on antibiotic resistance bacteria (ARB) and antibiotic resistance gene (ARG), accelerating the flow of antibiotic resistance. As ARG spreads to the population, the burden of antibiotic resistance in humans increases, which may have potential health effects on people. Therefore, it is critical to mitigate the spread of antibiotic resistance to humans and reduce the load of antibiotic resistance in humans. This review briefly described the information of global antibiotic consumption information and national action plans (NAPs) to combat antibiotic resistance and provided a set of feasible control strategies for the transmission of ARB and ARG to humans in three areas including (a) Reducing the colonization capacity of exogenous ARB, (b) Enhancing human colonization resistance and mitigating the horizontal gene transfer (HGT) of ARG, (c) Reversing ARB antibiotic resistance. With the hope of achieving interdisciplinary one-health prevention and control of bacterial resistance.