Anti-Pythium insidiosum activity of MSI-78, LL-37, and magainin-2 antimicrobial peptides

• Published in: Brazilian journal of microbiology Vol. 53; no. 1; pp. 509 - 512
• Main Authors: Denardi, Laura Bedin, Weiblen, Carla, Ianiski, Lara Baccarin, Stibbe, Paula Cristina, Pinto, Stefania Campos, Santurio, Janio M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2022; Springer Nature B.V
• Subjects: Animal diseases; Animals; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Antimicrobial Cationic Peptides; Antimicrobial Peptides; Biomedical and Life Sciences; Food Microbiology; Humans; Life Sciences; Magainins; Medical Microbiology; Microbial Ecology; Microbial Genetics and Genomics; Microbial Sensitivity Tests; Microbiology; Minimum inhibitory concentration; Mycology; Peptides; Pythium; Pythium insidiosum; Strains (organisms); Veterinary Microbiology - Short Communication; MSI-78; LL-37; Magainin-2; Antimicrobial peptides; Pythium insidiosum
• ISSN: 1517-8382; 1678-4405
• DOI: 10.1007/s42770-022-00678-5

We investigated the anti-Pythium insidiosum activity of the antimicrobial peptides (AMPs) MSI-78, LL-37, and magainin-2. To detect the minimum inhibitory concentration (MIC), fourteen clinical strains were incubated with the AMPs following the CLSI M38-A2 protocol. All three AMPs showed antimicrobial activity with an MIC range of 20–80 mg/L against all strains. We concluded that the evaluated AMPs have great potential as anti-Pythium insidiosum agents, and their activity deserves to be more explored in further research. Lay Abstract Antimicrobial peptides were tested against Pythium insidiosum , a microorganism that causes a difficult-to-treat disease in animals and humans. These peptides have been shown to be able to kill P. insidiosum and may be candidates for use in the treatment of this infection.