Does nesfatin-1 influence the hypothalamic–pituitary–gonadal axis in adult males with obstructive sleep apnoea?

• Published in: Scientific reports Vol. 9; no. 1; pp. 11289 - 5
• Main Authors: Batura-Gabryel, Halina, Bromińska, Barbara, Sawicka-Gutaj, Nadia, Cyrańska-Chyrek, Ewa, Kuźnar-Kamińska, Barbara, Winiarska, Hanna, Kostrzewska, Magdalena, Zybek-Kocik, Ariadna, Hernik, Aleksandra, Wrotkowska, Elżbieta, Bielawska, Lena, Cofta, Szczepan, Ruchała, Marek
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2019; Nature Publishing Group
• Subjects: 59; 692/163/2743/1526/1561; 692/699/1785; Aged; Alanine; Alanine transaminase; Apnea; Aspartate transaminase; Blood Glucose - analysis; C-reactive protein; Creatinine; Fasting; Gonads - metabolism; Humanities and Social Sciences; Humans; Hypothalamus; Hypothalamus - metabolism; Luteinizing hormone; Male; Males; Middle Aged; multidisciplinary; Nucleobindins - blood; Nucleobindins - metabolism; Pituitary; Pituitary Gland - metabolism; Polysomnography; Prospective Studies; Science; Science (multidisciplinary); Sleep; Sleep apnea; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - metabolism; Sleep deprivation; Sleep disorders; Testosterone; Transaminase
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-47061-3

There is growing evidence that obstructive sleep apnoea (OSA) influences the hypothalamic–pituitary–gonadal axis (HPG axis) in men. The aim of the study was to assess the association of nesfatin-1 with HPG axis disturbances in OSA. This is a prospective study with consecutive enrolment. It comprises 72 newly diagnosed OSA patients ((AHI: apnoea-hypopnea index) 18 subjects: 5 ≤ AHI < 15; 24: 15 ≤ AHI < 30; 30: AHI ≥ 30) and a control group composed of 19 patients (AHI < 5). All patients underwent polysomnography and fasting blood collection for nesfatin-1, testosterone, luteinising hormone (LH), high-sensitivity C-reactive protein (hsCRP), aspartate transaminase (AST), alanine aminotransferase (ALT), creatinine and glucose. Groups had similar levels of LH, nesfatin-1 and testosterone (p = 0.87; p = 0.24; p = 0.08). Nesfatin-1 was not correlated to LH (p = 0.71), testosterone (p = 0.38), AHI (p = 0.34) or the oxygen desaturation index (ODI) (p = 0.69) either in the whole group, or in sub-groups. The study did not reveal any association between the HPG axis and nesfatin-1 in OSA adult males. It is possible that nesfatin-1 is not a mediator of HPG axis disturbances in adult patients with OSA.