Implanted haemodynamic telemonitoring devices to guide management of heart failure: a review and meta-analysis of randomised trials

• Published in: Clinical research in cardiology Vol. 112; no. 8; pp. 1007 - 1019
• Main Authors: Iaconelli, Antonio, Pellicori, Pierpaolo, Caiazzo, Elisabetta, Rezig, Asma O. M., Bruzzese, Dario, Maffia, Pasquale, Cleland, John G. F.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2023; Springer Nature B.V
• Subjects: Cardiology; Clinical trials; Congestion; Congestive heart failure; Heart failure; Heart Failure - diagnosis; Heart Failure - therapy; Hemodynamics; Hospitalization; Humans; Medicine; Medicine & Public Health; Meta-analysis; Monitoring; Monitoring, Physiologic; Morbidity; Mortality; Pulmonary arteries; Pulmonary artery; Randomized Controlled Trials as Topic; Review; Risk reduction; State-of-the-art reviews; Telemedicine; Veins & arteries; Heart failure; Implantable devices; Pulmonary hypertension; Tele-monitoring
• ISSN: 1861-0684; 1861-0692; 1861-0692
• DOI: 10.1007/s00392-022-02104-0

Background and aims Congestion is a key driver of morbidity and mortality in heart failure. Implanted haemodynamic monitoring devices might allow early identification and management of congestion. Here, we provide a state-of-the-art review of implanted haemodynamic monitoring devices for patients with heart failure, including a meta-analysis of randomised trials. Methods and results We did a systematic search for pre-print and published trials in Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) on the 22nd of September 2021. We included randomised trials that compared management with or without information from implanted haemodynamic monitoring devices for patients with heart failure. Outcomes selected were hospitalisation for heart failure and all-cause mortality. Changes in treatment associated with haemodynamic monitoring resulted in only a small reduction in mean pulmonary artery pressure (typically < 1 mmHg as a daily average), which generally remained much greater than 20 mmHg. Haemodynamic monitoring reduced hospitalisations for heart failure (HR 0.75; 95% CI 0.58–0.96; p  = 0.03) but not mortality (RR 0.92; 95% CI 0.68–1.26; p  = 0.48). Conclusions Haemodynamic monitoring for patients with heart failure may reduce the risk of hospitalization for heart failure but this has not yet translated into a reduction in mortality, perhaps because the duration of trials was too short or the reduction in pulmonary artery pressure was not sufficiently large. The efficacy and safety of aiming for larger reductions in pulmonary artery pressure should be explored. Graphical abstract After selecting key words, a systematic review for implanted haemodynamic telemonitoring devices was performed in different dataset and 4 randomised clinical trials were identified and included in this meta-analysis. Three different devices (Chronicle, Chronicle/ICD and CardioMEMS) were tested. All-cause mortality and total heart failure hospitalisations were selected as outcomes. No reduction in all-cause mortality rate was reported but a potential benefit on total heart failure hospitalisation was identified.