Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?

• Published in: Biomedicine & pharmacotherapy Vol. 144; p. 112292
• Main Authors: Luan, Yi, Li, Mingli, Zhao, Yi, Li, Qianqian, Wen, Jia, Gao, Siqi, Yang, Yang
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.12.2021; Elsevier
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Cancer; Cell Cycle Proteins - antagonists & inhibitors; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Centrosomal-associated Proteins; Centrosome; Centrosome - drug effects; Centrosome - metabolism; Centrosome - pathology; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins - antagonists & inhibitors; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Signal Transduction; Structure; Therapeutic targets; Centrosomal-associated Proteins; Structure; Centrosome; Cancer; Therapeutic targets
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.112292

The centrosome is a special organelle in human cells and an organizing unit for microtubules and signaling molecules. In addition, the centrosome is tightly restricted during the cell cycle and forms the basal body of the cilia in ciliated cells. Centrosome abnormality is frequently observed in malignant tumors. The dysregulation of centrosome-associated proteins leads to multipolar mitosis, aneuploidy, and nondirected cell migration, and therefore promotes cancer progression. The overduplication of primary centrosome and the accumulation of chromosome, comprise the majority cause of chromosomal mis-segregation in cancer cells. This review discusses the structure and function of the centrosome and the role of its associated proteins in the progression of solid tumors. We summarized the effects of centrosome amplification abnormalities and other centrosome-related phenotypes on tumors. The mechanism of the delineation of centrosome amplification with tumor malignancy remains to be decided. A better understanding of centrosome abnormality in tumorigenesis may be useful to screen novel therapeutic strategies for the treatment of solid tumors. [Display omitted] •Centrosomes perform multiple functions in different cellular processes.•Centrosome abnormality are common in solid tumors.•Centrosome-associated regulators play critical roles in solid tumor progression.•Targeting tumor cells with extra centrosomes are novel therapeutics for solid tumor treatment.