Two types of clinical ictal direct current shifts in invasive EEG of intractable focal epilepsy identified by waveform cluster analysis

• Published in: Clinical neurophysiology Vol. 137; pp. 113 - 121
• Main Authors: Kajikawa, Shunsuke, Matsuhashi, Masao, Kobayashi, Katsuya, Hitomi, Takefumi, Daifu-Kobayashi, Masako, Kobayashi, Tamaki, Yamao, Yukihiro, Kikuchi, Takayuki, Yoshida, Kazumichi, Kunieda, Takeharu, Matsumoto, Riki, Kakita, Akiyoshi, Namiki, Takao, Tsuda, Ichiro, Miyamoto, Susumu, Takahashi, Ryosuke, Ikeda, Akio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2022
• Subjects: Cluster analysis; Glia; Ictal direct current shifts; Cluster analysis; AC; FCD; STFT; AQP4; Ictal direct current shifts; HS; TLE; LFF; iEEG; TC; HFO; IIR; Cx; ECoG; Glia; ATP; DC
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2022.02.021

•Ictal direct current shifts can be observed at a time constant of 2 s.•Two types of ictal direct current shifts were revealed by the waveform property.•Each type of direct current shift may be correlated with the corresponding pathology. To determine clinically ictal direct current (DC) shifts that can be identified by a time constant (TC) of 2 s and to delineate different types of DC shifts by different attenuation patterns between TC of 10 s and 2 s. Twenty-one patients who underwent subdural electrode implantation for epilepsy surgery were investigated. For habitual seizures, we compared (1) the peak amplitude and (2) peak latency of the earliest ictal DC shifts between TC of 10 s and 2 s. Cluster and logistic regression analyses were performed based on the attenuation rate of amplitude and peak latency with TC 10 s. Ictal DC shifts in 120 seizures were analyzed; 89.1% of which were appropriately depicted even by a TC of 2 s. Cluster and logistic regression analyses revealed two types of ictal DC shift. Namely, a rapid development pattern was defined as the ictal DC shifts with a shorter peak latency and they also showed smaller attenuation rate of amplitude (73/120 seizures). Slow development pattern was defined as the ictal DC shifts with crosscurrent of a rapid development pattern, i.e., a longer peak latency and larger attenuation rate of amplitude (47/120 seizures). Focal cortical dysplasia (FCD) 1A tended to show a rapid development pattern (22/29 seizures) and FCD2A tended to show a slow development pattern (13 /18 seizures), indicating there might be some correlations between two types of ictal DC shift and certain pathologies. Ictal DC shifts, especially rapid development pattern, can be recorded and identified by the AC amplifiers of TC of 2 s which is widely used in many institutes compared to that of TC of 10 s. Two types of ictal DC shifts were identified with possibility of corresponding pathology. Ictal DC shifts can be distinguished by their attenuation patterns.