Neutrophil homeostasis and its regulation by danger signaling

• Published in: Blood Vol. 123; no. 23; pp. 3563 - 3566
• Main Authors: Wirths, Stefan, Bugl, Stefanie, Kopp, Hans-Georg
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.06.2014
• Subjects: Animals; Feedback, Physiological; Granulocyte Colony-Stimulating Factor - physiology; Hematopoiesis - genetics; Homeostasis - immunology; Humans; Immunity, Innate - physiology; Mice; Microbiota - physiology; Neutrophils - physiology; Signal Transduction - physiology; Toll-Like Receptor 4 - physiology

Hematopoiesis in general is demand driven and adaptive, but in contrast to erythropoiesis or thrombocytopoiesis, our knowledge on how neutrophil production is adapted to individual needs remains incomplete. Recently, neutrophil homeostasis has been shown to depend on danger receptors, macrophages, a...