Neutrophil homeostasis and its regulation by danger signaling

Hematopoiesis in general is demand driven and adaptive, but in contrast to erythropoiesis or thrombocytopoiesis, our knowledge on how neutrophil production is adapted to individual needs remains incomplete. Recently, neutrophil homeostasis has been shown to depend on danger receptors, macrophages, a...

Full description

Saved in:
Bibliographic Details
Published inBlood Vol. 123; no. 23; pp. 3563 - 3566
Main Authors Wirths, Stefan, Bugl, Stefanie, Kopp, Hans-Georg
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 05.06.2014
Subjects
Animals
Feedback, Physiological
Granulocyte Colony-Stimulating Factor - physiology
Hematopoiesis - genetics
Homeostasis - immunology
Humans
Immunity, Innate - physiology
Mice
Microbiota - physiology
Neutrophils - physiology
Signal Transduction - physiology
Toll-Like Receptor 4 - physiology
Online AccessGet full text

Cover

More Information
Summary:Hematopoiesis in general is demand driven and adaptive, but in contrast to erythropoiesis or thrombocytopoiesis, our knowledge on how neutrophil production is adapted to individual needs remains incomplete. Recently, neutrophil homeostasis has been shown to depend on danger receptors, macrophages, and even circadian rhythms. Puzzle pieces for a broader view of neutrophil homeostasis accumulate, and we will herein try to put seemingly contradictory evidence in a perspective of neutrophil homeostasis and emergency granulopoiesis determined by innate immunologic signaling.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2013-11-516260