Clinical Features of Neuroblastoma with 11q Deletion: An Increase in Relapse Probabilities in Localized and 4S Stages

Neuroblastoma (NB) is a heterogeneous tumor with an extremely diverse prognosis according to clinical and genetic factors, such as the presence of an 11q deletion (11q-del). A multicentric study using data from a national neuroblastic tumor database was conducted. This study compared the most import...

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Published inScientific reports Vol. 9; no. 1; p. 13806
Main Authors Juan Ribelles, Antonio, Barberá, Sandra, Yáñez, Yania, Gargallo, Pablo, Segura, Vanessa, Juan, Bárbara, Noguera, Rosa, Piqueras, Marta, Fornés-Ferrer, Victoria, de Mora, Jaime Font, Cañete, Adela, Castel, Victoria
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 24.09.2019
Nature Publishing Group
Subjects
13/105
38/61
45/41
692/4017
692/4028/67/2332
692/53/2422
Genetic factors
Humanities and Social Sciences
Medical prognosis
multidisciplinary
Neuroblastoma
Risk groups
Science
Science (multidisciplinary)
Survival
Tumors
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Summary:Neuroblastoma (NB) is a heterogeneous tumor with an extremely diverse prognosis according to clinical and genetic factors, such as the presence of an 11q deletion (11q-del). A multicentric study using data from a national neuroblastic tumor database was conducted. This study compared the most important features of NB patients: presence of 11q-del, presence of MYCN amplification (MNA) and remaining cases. A total of 357 patients were followed throughout an 8-year period. 11q-del was found in sixty cases (17%). 11q-del tumors were diagnosed at an older age (median 3.29 years). Overall survival (OS) was lower in 11q-del patients (60% at 5 years), compared to all other cases (76% at 5 years) p = 0.014. Event free survival (EFS) was 35% after 5 years, which is a low number when compared with the remaining cases: 75% after 5 years (p < 0.001). Localized tumors with 11q-del have a higher risk of relapse (HR = 3.312) such as 4 s 11q-del patients (HR 7.581). 11q-del in NB is a dismal prognostic factor. Its presence predicts a bad outcome and increases relapse probability, specially in localized stages and 4 s stages. The presence of 11q aberration should be taken into consideration when stratifying neuroblastoma risk groups.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-50327-5