ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis

• Published in: Archives of toxicology Vol. 97; no. 6; pp. 1439 - 1451
• Main Authors: Wang, Bingqing, Wang, Yue, Zhang, Jing, Hu, Chang, Jiang, Jun, Li, Yiming, Peng, ZhiYong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2023; Springer Nature B.V
• Subjects: 4-Hydroxynonenal; Apoptosis; autophagosomes; Autophagy; Biomedical and Life Sciences; Biomedicine; Cell Death; Endoplasmic reticulum; endoplasmic reticulum stress; Environmental Health; Ferroptosis; Lipid Peroxidation; Lipids; Mitochondria; Mortality; Occupational Medicine/Industrial Medicine; Oxidation; Peroxidation; Peroxides; Phagosomes; Pharmacology/Toxicology; Phospholipids; Reactive oxygen species; Reactive Oxygen Species - metabolism; Review Article; Ferroptosis; Reactive oxygen species; Autophagy; Lipid peroxides; Apoptosis

Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal and other related products, which play an important role in the process of cell death, including apoptosis, autophagy, and ferroptosis. Lipid peroxidation of phospholipid bilayers can promote mitochondrial apoptosi...