Dorsal BNST DRD2+ neurons mediate sex-specific anxiety-like behavior induced by chronic social isolation
The dorsal bed nucleus of stria terminalis (dBNST) is a pivotal hub for stress response modulation. Dysfunction of dopamine (DA) network is associated with chronic stress, but the roles of DA network of dBNST in chronic stress-induced emotional disorders remain unclear. We examine the role of dBNST...
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Published in | Cell reports (Cambridge) Vol. 42; no. 7; p. 112799 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
25.07.2023
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The dorsal bed nucleus of stria terminalis (dBNST) is a pivotal hub for stress response modulation. Dysfunction of dopamine (DA) network is associated with chronic stress, but the roles of DA network of dBNST in chronic stress-induced emotional disorders remain unclear. We examine the role of dBNST Drd1+ and Drd2+ neurons in post-weaning social isolation (PWSI)-induced behavior deficits. We find that male, but not female, PWSI rats exhibit negative emotional phenotypes and the increase of excitability and E-I balance of dBNST Drd2+ neurons. More importantly, hypofunction of dBNST Drd2 receptor underlies PWSI-stress-induced male-specific neuronal plasticity change of dBNST Drd2+ neurons. Furthermore, chemogenetic activation of dBNST Drd2+ neurons is sufficient to induce anxiogenic effects, while Kir4.1-mediated chronic inhibition of dBNST Drd2+ neurons ameliorate PWSI-induced anxiety-like behaviors. Our findings reveal an important neural mechanism underlying PWSI-induced sex-specific behavioral abnormalities and potentially provide a target for the treatment of social stress-related emotional disorder.
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•PWSI stress induces male-specific emotional and social dysfunction•Excitability of dBNST Drd2+, but not Drd1+, neurons of PWSI rats shows an increase•There is an enhancement of E:I balance of dBNST Drd2+ neurons in PWSI rats•Inhibition of dBNST Drd2+ neurons rescues anxiety-like phenotype caused by PWSI stress
Zheng et al. find an important mechanism by which post-weaning social isolation stress induces male-specific anxiety-like behavior by the increase of the excitability of dBNST Drd2+, but not Drd1+, neurons and enhancement of E:I balance of dBNST Drd2+ neurons. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2211-1247 2211-1247 |
DOI: | 10.1016/j.celrep.2023.112799 |