Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats:possible role of decreased lecithin cholesterol acetyl transferase activity

• Published in: Asian Pacific journal of tropical medicine Vol. 4; no. 8; pp. 658 - 660
• Main Authors: Kumar, VR Santhosh, Inamdar, Md Naseeruddin, Nayeemunnisa, Viswanatha, GL
• Format: Journal Article
• Language: English
• Published: India Elsevier B.V 01.08.2011; Department of Pharmacology, Al-Ameen College of Pharmacy, Hosur Road, Bangalore, India%Department of Pharmacology, PES College of Pharmacy, Hanumanthanagar, Bangalore, India
• Subjects: activity; Animals; Atorvastatin Calcium; Cholesterol - blood; Cymbopogon - chemistry; Dexamethasone; Dexamethasone - adverse effects; Dexametliasone; Heptanoic Acids - pharmacology; Hvperlipidemia; Hyperlipidemia; Hyperlipidemias - blood; Hyperlipidemias - chemically induced; Hyperlipidemias - drug therapy; Hypolipidemic Agents - chemistry; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Lemongrass; Lemongrass oil; Lipid-lowering; Lipid-lowering activity; Male; oil; Phosphatidylcholine-Sterol O-Acyltransferase - antagonists & inhibitors; Phosphatidylcholine-Sterol O-Acyltransferase - metabolism; Phytotherapy - methods; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Oils - chemistry; Plant Oils - pharmacology; Plant Oils - therapeutic use; Pyrroles - pharmacology; Rats; Rats, Wistar; Terpenes - chemistry; Terpenes - pharmacology; Terpenes - therapeutic use; Triglycerides - blood; Dexamethasone; Hyperlipidemia; Lipid-lowering activity; Lemongrass oil
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(11)60167-3

<正>Objective:To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats.Methods:Administration of dexamethasone was given at 10 mg/kg,sc.to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index.Results:Lemongrass oil(100 and 200 mg/kg,po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg,po.The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase(LCAT) activity.Conclusions:These results suggested that Lemon gross oil possess significant antihyperlipidemic activity.