New insight and potential therapy for NAFLD: CYP2E1 and flavonoids

• Published in: Biomedicine & pharmacotherapy Vol. 137; p. 111326
• Main Authors: Wang, Kaiyue, Tan, Wangxiao, Liu, Xiao, Deng, Lina, Huang, Lu, Wang, Xiaoying, Gao, Xiumei
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.05.2021; Elsevier
• Subjects: CYP2E1; Flavonoids; NAFL; NAFLD; NASH; NAFLD; AFLD; IRS1; ERS; HFD; LPO; IRS2; MDA; PPAR γ; NF-κB; OA; UPR; RNS; MEOS; NAFL; ApoB; CYP 450; EC; ACC; OS; EGCG; ECG; IR; HCC; SOD; cJNK; NASH; SREBP-1c; MCD; AP; FFAs; Flavonoids; TG; SCD; ROS; 3-NT; ALD; HSCs; CYP2E1
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.111326

[Display omitted] •Non-alcoholic fatty liver disease is complex and includes many mechanisms.•CYP2E1 play a crucial role in non-alcoholic fatty liver disease.•CYP2E1 is involved in lipid metabolism and produces reactive oxygen species.•Flavonoids can inhibit the activity of CYP2E1 and alleviate oxidative stress level. Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity.