Aspirin resistance and a single gene

This study examined the association of single nucleotide polymorphisms in 4 candidate genes in a cohort of subjects with aspirin resistance. Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1.

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Bibliographic Details
Published inThe American journal of cardiology Vol. 95; no. 6; pp. 805 - 808
Main Authors Jefferson, Brian K., Foster, Jennifer H., McCarthy, Jeanette J., Ginsburg, Geoffrey, Parker, Alex, Kottke-Marchant, Kandice, Topol, Eric J.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.03.2005
Elsevier
Elsevier Limited
Subjects
Alleles
Angioplasty, Balloon, Coronary
Aspirin
Aspirin - administration & dosage
Biological and medical sciences
Blood Platelets - metabolism
Blood products
Cardiology
Cardiology. Vascular system
Coronary Disease - genetics
Coronary Disease - therapy
DNA Mutational Analysis
Drug resistance
Drug Resistance - genetics
Exons
Gene expression
Genetic Markers - genetics
Genotype
Homozygote
Humans
Linkage Disequilibrium
Mathematical Computing
Medical sciences
Platelet Aggregation - drug effects
Platelet Aggregation - genetics
Platelet Aggregation Inhibitors - administration & dosage
Polymorphism, Single Nucleotide - genetics
Premedication
Receptors, Purinergic P2 - genetics
Receptors, Purinergic P2Y1
Resistance
Gene
Acetylsalicylic acid
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Summary:This study examined the association of single nucleotide polymorphisms in 4 candidate genes in a cohort of subjects with aspirin resistance. Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1.
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ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.11.045