Cluster of Fusarium verticillioides bloodstream infections among immunocompetent patients in an internal medicine department after reconstruction works in Larissa, Central Greece

• Published in: The Journal of hospital infection Vol. 86; no. 4; pp. 267 - 271
• Main Authors: Georgiadou, S.P, Velegraki, A, Arabatzis, M, Neonakis, I, Chatzipanagiotou, S, Dalekos, G.N, Petinaki, E
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2014; Elsevier
• Subjects: Aged; Aged, 80 and over; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Cross Infection - epidemiology; Cross Infection - microbiology; Diagnostic Tests, Routine; Environmental Microbiology; Fungemia - epidemiology; Fungemia - microbiology; Fusariosis - epidemiology; Fusariosis - microbiology; Fusarium - classification; Fusarium - isolation & purification; Fusarium verticillioides; General aspects; Greece - epidemiology; Hospital Departments; Human bacterial diseases; Human infectious diseases. Experimental studies and models; Humans; Infection Control - methods; Infectious Disease; Infectious diseases; Male; Medical sciences; Microbiological Techniques; Middle Aged; Nosocomial outbreak; Reconstruction; Greece; Europe; Reconstruction; Nosocomial outbreak; Fusarium verticillioides; Epidemic; Human; Nosocomial infection; Bacteremia; Fungi; Infection; Bacteriosis; General practice; Fungi Imperfecti; Fusariotoxicosis; Public health
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1016/j.jhin.2014.01.011

Summary Background Fusarium spp. can cause disseminated infections, particularly in immunocompromised patients. Fusarium verticillioides is a human pathogen, and sporadic cases of fusariosis have been reported. Aim To report a nosocomial cluster of F. verticillioides bloodstream infections among seven immunocompetent inpatients following reconstruction works. Methods Identification was performed using macroscopic and microscopic morphology, and molecular assays (sequencing the nuclear ribosomal internal transcribed spacer region and translation elongation factor-1α gene). Susceptibility testing was performed in accordance with the guidelines of the Clinical and Laboratory Standards Institute. Environmental surveillance specimens were taken and cultured on Sabouraud dextrose agar plates. Findings In total, 16 blood cultures obtained from the seven patients were positive for F. verticillioides . All surveillance cultures were negative. Conclusions In order to prevent fungaemia, it is important to implement effective infection control measures, before, during and after demolition and construction activities in healthcare settings.