Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases

• Published in: Journal of assisted reproduction and genetics Vol. 38; no. 12; pp. 3243 - 3249
• Main Authors: Le, Ho Long, Ho, Vu Ngoc Anh, Le, Tam Thi Ngan, Tran, Van Thi Thu, Ma, Mai Pham Que, Le, Anh Hoang, Nguyen, Linh Khanh, Ho, Tuong Manh, Vuong, Lan Ngoc
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021; Springer Nature B.V
• Subjects: Adult; Amenorrhea; Chorionic gonadotropin; Chorionic Gonadotropin - metabolism; Embryo Transfer - methods; Embryos; Female; Fertility; Fertilization in Vitro - methods; Follicle-stimulating hormone; Gonadotropins; Gynecology; Human Genetics; Humans; Hypogonadism; In Vitro Oocyte Maturation Techniques - methods; Infertility; Infertility, Female - metabolism; Infertility, Female - physiopathology; Live Birth; Medicine; Medicine & Public Health; Ovaries; Ovary - metabolism; Ovary - physiology; Patients; Pituitary (anterior); Pregnancy; Pregnancy, Multiple - metabolism; Pregnancy, Multiple - physiology; Primary Ovarian Insufficiency - metabolism; Primary Ovarian Insufficiency - physiopathology; Receptors, FSH - metabolism; Reproductive Medicine; Reproductive Physiology and Disease; Secondary sexual characters; Live birth; Gonadotropin-resistant ovary syndrome; Infertility; In vitro maturation
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1007/s10815-021-02355-2

Purpose Gonadotropin-resistant ovary syndrome (GROS) is a rare endocrine disorder that causes hypergonadotropic hypogonadism, amenorrhea, and infertility. This study reports live birth in two women with GROS who underwent fertility treatment with in vitro maturation (IVM). Methods Both patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified. Results Both patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy. Conclusions These results suggest that IVM should be a first-line therapeutic option for patients with GROS.