Early Atherosclerotic Changes in Coronary Arteries are Associated with Endothelium Shear Stress Contraction/Expansion Variability

• Published in: Annals of biomedical engineering Vol. 49; no. 9; pp. 2606 - 2621
• Main Authors: Mazzi, Valentina, De Nisco, Giuseppe, Hoogendoorn, Ayla, Calò, Karol, Chiastra, Claudio, Gallo, Diego, Steinman, David A., Wentzel, Jolanda J., Morbiducci, Umberto
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2021; Springer Nature B.V
• Subjects: Animals; Arteries; Arteriosclerosis; Atherosclerosis; Atherosclerosis - physiopathology; Biochemistry; Biological and Medical Physics; Biomechanics; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Classical Mechanics; Computer applications; Contraction; Coronary artery; Coronary vessels; Coronary Vessels - physiopathology; Endothelium; Endothelium, Vascular - physiopathology; Expansion; Hemodynamics; Mechanical stimuli; Models, Cardiovascular; Original; Original Article; Shear stress; Stress, Mechanical; Swine; Swine, Miniature; Thickening; Topology; Variability; Wall shear stresses; Topological skeleton; Plaque progression; Wall shear stress; Computational fluid dynamics; Topological shear variation index; Atherosclerosis
• ISSN: 0090-6964; 1573-9686
• DOI: 10.1007/s10439-021-02829-5

Although unphysiological wall shear stress (WSS) has become the consensus hemodynamic mechanism for coronary atherosclerosis, the complex biomechanical stimulus affecting atherosclerosis evolution is still undetermined. This has motivated the interest on the contraction/expansion action exerted by WSS on the endothelium, obtained through the WSS topological skeleton analysis. This study tests the ability of this WSS feature, alone or combined with WSS magnitude, to predict coronary wall thickness (WT) longitudinal changes. Nine coronary arteries of hypercholesterolemic minipigs underwent imaging with local WT measurement at three time points: baseline (T1), after 5.6 ± 0.9 (T2), and 7.6 ± 2.5 (T3) months. Individualized computational hemodynamic simulations were performed at T1 and T2. The variability of the WSS contraction/expansion action along the cardiac cycle was quantified using the WSS topological shear variation index ( TSVI ). Alone or combined, high TSVI and low WSS significantly co-localized with high WT at the same time points and were significant predictors of thickening at later time points. TSVI and WSS magnitude values in a physiological range appeared to play an atheroprotective role. Both the variability of the WSS contraction/expansion action and WSS magnitude, accounting for different hemodynamic effects on the endothelium, (1) are linked to WT changes and (2) concur to identify WSS features leading to coronary atherosclerosis.