Genetics of rheumatoid arthritis: an impressionist perspective

Rheumatoid arthritis (RA) is the most common rheumatic disease. The genetic basis of RA is supported through the identification of more than 30 susceptibility genetic variants. Each of these genes individually makes only a slight contribution to the risk of disease. Moreover, there is significant di...

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Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 38; no. 2; p. 243
Main Authors Jacob, Noam, Jacob, Chaim O
Format Journal Article
LanguageEnglish
Published United States 01.05.2012
Subjects
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - genetics
Ethnic Groups
Genetic Predisposition to Disease
Genetic Variation
HLA-A Antigens - genetics
Humans
Multifactorial Inheritance
Risk Factors
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Summary:Rheumatoid arthritis (RA) is the most common rheumatic disease. The genetic basis of RA is supported through the identification of more than 30 susceptibility genetic variants. Each of these genes individually makes only a slight contribution to the risk of disease. Moreover, there is significant disparity in the genetic variants associated with different RA subgroups and patient ethnicities, which emphasizes the intricate nature of the disease's pathogenesis, and the complexities involved in large-scale genetic studies. This review evaluates critically the recent literature on the genetic contribution to RA and assesses the methodology used to identify these risk alleles.
ISSN:1558-3163
DOI:10.1016/j.rdc.2012.05.001