Antibiotic prophylaxis in penetrating traumatic brain injury: analysis of a single-center series and systematic review of the literature

• Published in: Acta neurochirurgica Vol. 165; no. 2; pp. 303 - 313
• Main Authors: Ganga, Arjun, Leary, Owen P., Sastry, Rahul A., Asaad, Wael F., Svokos, Konstantina A., Oyelese, Adetokunbo A., Mermel, Leonard A.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.02.2023; Springer Nature B.V
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibiotic Prophylaxis; Antibiotics; Antimicrobial agents; Brain Injuries, Traumatic - drug therapy; Central nervous system; Disease prevention; Head Injuries, Penetrating; Humans; Infection; Infections; Interventional Radiology; Literature reviews; Medicine; Medicine & Public Health; Meningitis; Minimally Invasive Surgery; Neurology; Neuroradiology; Neurosurgery; Prophylaxis; Review - Infection; Review Article - Infection; Surgical Orthopedics; Systematic review; Traumatic brain injury; Wound Infection; Gun violence; Penetrating trauma; Traumatic brain injury; CNS infection
• ISSN: 0942-0940; 0001-6268; 0942-0940
• DOI: 10.1007/s00701-022-05432-2

Purpose Penetrating traumatic brain injury (pTBI) is an acute medical emergency with a high rate of mortality. Patients with survivable injuries face a risk of infection stemming from foreign body transgression into the central nervous system (CNS). There is controversy regarding the utility of antimicrobial prophylaxis in managing such patients, and if so, which antimicrobial agent(s) to use. Methods We reviewed patients with pTBI at our institution and performed a PRISMA systematic review to assess the impact of prophylactic antibiotics on reducing risk of CNS infection. Results We identified 21 local patients and 327 cases in the literature. In our local series, 17 local patients received prophylactic antibiotics; four did not. Overall, five of these patients (24%) developed a CNS infection (four and one case of intraparenchymal brain abscess and meningitis, respectively). All four patients who did not receive prophylactic antibiotics developed an infection (three with CNS infections; one superficial wound infection) compared to two of 17 (12%) patients who did receive prophylactic antibiotics. Of the 327 pTBI cases reported in the literature, 216 (66%) received prophylactic antibiotics. Thirty-eight (17%) patients who received antibiotics developed a CNS infection compared to 21 (19%) who did not receive antibiotics ( p  = 0.76). Conclusions Although our review of the literature did not reveal any benefit, our institutional series suggested that patients with pTBI may benefit from prophylactic antibiotics. We propose a short antibiotic course with a regimen specific to cases with and without the presence of organic debris.