P2X7Rs: new therapeutic targets for osteoporosis

Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor...

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Published inPurinergic signalling Vol. 19; no. 1; pp. 207 - 219
Main Authors Huang, Haoyun, He, Yu-Mei, Lin, Miao-Miao, Wang, Yanchao, Zhang, Xiaomei, Liang, Li, He, Xueling
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Bone and Bones
Bone growth
Bone resorption
Bone turnover
Cancer Research
Homeostasis
Human Physiology
Humans
Inflammation
Neurosciences
Osteoblasts
Osteoclasts
Osteogenesis
Osteoporosis
Pharmacology/Toxicology
Receptors, Purinergic P2X7
Review
Review Article
Therapeutic targets
Osteoporosis
Osteoclasts
Inflammation
P2X7 receptor
Osteoblasts
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Abstract Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.
AbstractList Abstract Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.
Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.
Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.
Author Huang, Haoyun
Liang, Li
Lin, Miao-Miao
He, Yu-Mei
Zhang, Xiaomei
Wang, Yanchao
He, Xueling
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  fullname: He, Xueling
  email: hxlscu@163.com
  organization: Laboratory Animal Center of Sichuan University
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Cites_doi 10.1016/j.biopha.2020.110010
10.1089/scd.2010.0576
10.1016/j.burns.2012.08.013
10.1096/fj.14-257923
10.1124/mol.107.035980
10.1002/stem.1411
10.1371/journal.pone.0107224
10.1038/ejhg.2011.253
10.1016/j.yexcr.2019.111555
10.1038/s41574-020-0341-0
10.1016/j.redox.2017.10.021
10.1111/j.1469-7793.1998.495bh.x
10.1097/GME.0000000000000991
10.1016/bs.apcsb.2015.11.004
10.4049/jimmunol.135.3.1786
10.1126/science.272.5262.735
10.1074/jbc.M105881200
10.1007/s00223-009-9237-7
10.1074/jbc.M006781200
10.1016/j.bone.2018.09.012
10.1210/endo.136.7.7789332
10.1007/s00198-012-2059-x
10.1038/s41419-018-1253-y
10.1016/j.gene.2020.145362
10.1089/ars.2013.5467
10.1073/pnas.062053399
10.1080/13697137.2019.1604654
10.4049/jimmunol.180.2.1080
10.2741/208
10.1016/j.bonr.2015.09.003
10.1007/s00223-002-2098-y
10.2741/3873
10.3389/fmed.2020.00506
10.1016/j.bcp.2021.114425
10.1002/jcp.27976
10.1038/s41574-018-0059-4
10.1002/stem.1356
10.1055/a-1113-0711
10.1016/j.arr.2015.08.004
10.1016/j.bone.2018.01.019
10.1007/s11302-009-9139-1
10.1074/jbc.M605620200
10.1371/journal.pone.0069057
10.1016/j.bcp.2017.12.021
10.1091/mbc.e04-10-0912
10.1189/jlb.3MR0516-224R
10.1210/en.2007-0066
10.1074/jbc.M507816200
10.1152/ajpcell.00361.2003
10.1016/j.jhazmat.2020.124251
10.1152/ajpcell.2000.279.2.C510
10.1002/jcp.27544
10.1016/j.immuni.2017.06.020
10.1074/jbc.M010353200
10.1007/s11302-016-9495-6
10.1159/000431091
10.1016/j.bone.2007.09.058
10.1182/blood-2004-03-0834
10.1002/cmdc.202000303
10.1038/s41392-021-00553-z
10.1016/j.bone.2008.02.017
10.1359/jbmr.2001.16.5.846
10.1074/jbc.M506415200
10.1016/S0065-2776(07)95005-1
10.1007/s00198-012-2035-5
10.1016/j.bone.2012.06.013
10.1007/s11302-009-9167-x
10.1007/s00406-021-01306-3
10.1001/jama.2019.18343
10.1210/me.2003-0021
10.1038/s41586-021-03795-7
10.1016/j.jhsa.2018.07.006
10.1186/1471-2172-5-16
10.1111/jcmm.16048
10.1007/s00005-015-0377-3
10.1152/ajpendo.00209.2011
10.1083/jcb.200708037
10.1007/s00264-007-0406-x
10.1038/ejhg.2011.245
10.1016/j.copbio.2020.11.001
10.1530/JOE-19-0518
10.1172/JCI11066
10.1016/j.jsbmb.2018.02.005
10.1007/s00774-020-01153-7
10.1093/ndt/gfy115
10.1016/j.coph.2019.02.013
10.1073/pnas.0505168102
10.1530/JME-14-0226
10.1038/cddis.2011.49
10.1016/s8756-3282(00)00351-3
10.1073/pnas.88.12.5134
10.1155/2014/954530
10.1007/s11302-010-9181-z
10.1007/s11302-013-9381-4
10.1038/d41586-021-02118-0
10.1016/j.bone.2018.01.007
10.1016/j.bone.2006.02.063
10.18632/aging.100444
10.1159/000283480
10.1111/bph.15299
10.1359/JBMR.041009
10.1074/jbc.M104608200
10.1007/s00774-017-0862-3
10.1007/s11914-020-00572-9
10.3389/fendo.2012.00041
10.1016/j.bbrc.2008.05.066
10.1007/s00774-010-0160-9
10.1016/s1568-1637(03)00030-8
10.1007/s00418-014-1194-1
10.1016/j.lfs.2018.07.048
10.1080/14656566.2020.1787381
10.4049/jimmunol.176.7.3877
10.1155/2021/5556122
10.1016/s1297-9589(01
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Issue 1
Keywords Osteoporosis
Osteoclasts
Inflammation
P2X7 receptor
Osteoblasts
Language English
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References Wesselius, Bours, Agrawal, Gartland, Dagnelie, Schwarz, Jorgensen (CR41) 2011; 1
Nakamura, Uezono, Narusawa, Shibuya, Oishi, Tanaka, Yanagihara, Nakamura, Izumi (CR67) 2000; 279
Ma, Ran, Cao, Zhao, Song, Zou, Gu, Yuan, Bian, Zhu, Liu (CR15) 2021; 5
Liu, Genetos, Shao, Geist, Li, Ke, Turner, Duncan (CR74) 2008; 42
Baldini, Mastropasqua, Francucci, D'Erasmo (CR9) 2005; 28
Mishto, Santoro, Bellavista, Bonafé, Monti, Franceschi (CR29) 2003; 2
Di Virgilio, Dal Ben, Sarti, Giuliani, Falzoni (CR87) 2017; 47
Gratal, Lamuedra, Medina, Bermejo-Álvarez, Largo, Herrero-Beaumont, Mediero (CR85) 2020; 28
Pellanda, Ghosh, O'Toole (CR31) 2021; 70
Tedder, Crain, Kubagawa, Clement, Cooper (CR90) 1985; 135
Li, Liu, Ke, Duncan, Turner (CR81) 2005; 280
D'Amelio, Grimaldi, Di Bella, Brianza, Cristofaro, Tamone, Giribaldi, Ulliers, Pescarmona, Isaia (CR22) 2008; 43
Knapik, Perera, Nam, Blazek, Rath, Leblebicioglu, Das, Wu, Hewett, Agarwal, Robling, Flanigan, Lee, Agarwal (CR112) 2014; 20
Brandao-Burch, Key, Patel, Arnett, Orriss (CR59) 2012; 19
Chotiyarnwong, McCloskey (CR5) 2020; 16
Jørgensen (CR11) 2019; 47
Husted, Harsløf, Stenkjær, Carstens, Jørgensen, Langdahl (CR96) 2013; 24
Cenci, Weitzmann, Roggia, Namba, Novack, Woodring, Pacifici (CR25) 2000; 106
Morrison, Turin, King, Burnstock, Arnett (CR60) 1998; 511
Kvist, Syberg, Petersen, Ding, Jørgensen, Schwarz (CR48) 2015; 23
Hiken, Steinberg (CR55) 2004; 287
Ma, Zhao, Chile, Wang, Zheng, Song, Zou, Gu, YanYuan, Liu (CR92) 2019; 383
Lu, Zhou, Ma, Lu, Lei, Du, Chen (CR17) 2020; 24
Sharma, Larriera, Palacio-Mancheno, Gatti, Fritton, Bromage, Cardoso, Doty, Fritton (CR1) 2018; 110
Wang, Jacobsen, Bengtsson, Erlinge (CR50) 2004; 3
Karkache, Damodaran, Molstad, Bradley (CR80) 2021; 1
Macedo, Magnani, Carvalho, Bruna-Romero, Gazzinelli, Oliveira (CR45) 2008; 180
Surprenant, Rassendren, Kawashima, North, Buell (CR61) 1996; 272
Ambrosi, Marecic, McArdle, Sinha, Gulati, Tong, Wang, Steininger, Hoover, Koepke, Murphy, Sokol, Seo, Tevlin, Lopez, Brewer, Mascharak, Lu, Ajanaku, Conley, Seita, Morri, Neff, Sahoo, Yang, Weissman, Longaker, Chan (CR39) 2021; 597
Genetos, Geist, Liu, Donahue, Duncan (CR76) 2005; 20
Sun, Scott (CR88) 2016; 100
David (CR27) 2007; 95
Du, Zhou, Zhu, Hu, Lu, Shi, Chen, Chen (CR18) 2018; 117
Naemsch, Dixon, Sims (CR57) 2001; 276
Matsushita, Ono, Ono (CR38) 2020; 18
De Marchi, Orioli, Dal Ben, Adinolfi (CR93) 2016; 104
Pournara, Durner, Kritsi, Papakostas, Zoumpoulakis, Nicke, Koufaki (CR107) 2020; 15
Illes, Müller, Jacobson, Grutter, Nicke, Fountain, Kennedy, Schmalzing, Jarvis, Stojilkovic, King, Di Virgilio (CR104) 2021; 178
Noronha-Matos, Coimbra, Sá-e-Sousa, Rocha, Marinhas, Freitas, Guerra-Gomes, Ferreirinha, Costa, Correia-de-Sá (CR65) 2014; 28
Li, Meyer, Duncan, Turner (CR115) 2009; 84
Dong, Chen, Zhang, Tian, Dong (CR14) 2020; 125
Agrawal, Jørgensen (CR12) 2021; 187
Barbosa, Leon, Nogueira-Pedro, Wasinsk, Araújo, Miranda, Ferreira, Paredes-Gamero (CR51) 2011; 2
Orriss, Utting, Brandao-Burch, Colston, Grubb, Burnstock, Arnett (CR75) 2007; 148
Zippel, Limbach, Ratajski, Urban, Luparello, Pansky, Kassack, Tobiasch (CR63) 2012; 21
Varley, Hughes, Greeves, Fraser, Sale (CR102) 2018; 108
Biver, Wang, Gartland, Orriss, Arnett, Boeynaems, Robaye (CR62) 2013; 31
Zeng, Yao, Zhao (CR95) 2019; 234
Zhang, Li, Gao, Guo, Xu, Li, Liu, Huang, Tu, Peng, Qiu, Fan, Zhu, Yu, Zheng, Liang (CR108) 2013; 39
Burnstock, Arnett, Orriss (CR13) 2013; 9
Eikelenboom, van Exel, Hoozemans, Veerhuis, Rozemuller, van Gool (CR30) 2010; 7
Panupinthu, Zhao, Possmayer, Ke, Sims, Dixon (CR72) 2007; 282
Gartland, Buckley, Bowler, Gallagher (CR53) 2003; 73
Zhou, Luo, Qi, Li, Gorodeski (CR94) 2009; 5
Jørgensen, Henriksen, Sørensen, Eriksen, Civitelli, Steinberg (CR58) 2002; 277
Raterman, Bultink, Lems (CR6) 2020; 21
Franceschi, Garagnani, Parini, Giuliani, Santoro (CR32) 2018; 14
Pierrefite-Carle, Santucci-Darmanin, Breuil, Camuzard, Carle (CR36) 2015; 24
Guo, Masin, Qureshi, Murrell-Lagnado (CR103) 2007; 72
Cherian, Siller-Jackson, Gu, Wang, Bonewald, Sprague, Jiang (CR84) 2005; 16
Habib, Dreymueller, Rösing, Botung, Slowik, Zendedel, Habib, Hoffmann, Beyer (CR19) 2018; 178
Zhang, Hou, Zou, Luo, Zhang, Wang, Wang (CR78) 2018; 14
Hoebertz, Townsend-Nicholson, Glass, Burnstock, Arnett (CR56) 2000; 27
Chen, Dou, Yi, Tang, Yu, Zhou, Luo, Liang, Yin, Li, Kang, Zhao, Dong (CR110) 2018; 1
Gartland, Hipskind, Gallagher, Bowler (CR46) 2001; 16
Salminen, Kaarniranta, Kauppinen (CR37) 2012; 4
Grol, Panupinthu, Korcok, Sims, Dixon (CR47) 2009; 5
CR2
Greenblatt, Debnath (CR40) 2021; 597
Varley, Greeves, Sale, Friedman, Moran, Yanovich, Wilson, Gartland, Hughes, Stellingwerff, Ranson, Fraser, Gallagher (CR116) 2016; 12
Xiao, Gong, Liu, Liu, Peng, Luo, Wang, Li, Zhao, Xiong, Liang, Xu (CR20) 2019; 22
Wesselius, Bours, Henriksen, Syberg, Petersen, Schwarz, Jørgensen, van Helden, Dagnelie (CR99) 2013; 24
Gu, Zhang, Worthington, Sluyter, Dao-Ung, Petrou, Barden, Wiley (CR101) 2001; 276
CR86
Orriss, Knight, Ranasinghe, Burnstock, Arnett (CR66) 2006; 39
Liu, Rao, Gong, Li, Ding, Wang, Zhong, Wang, Zhao, Zhou, Xiong, Tu, Liang, Xu (CR98) 2018; 25
Shemon, Sluyter, Fernando, Clarke, Dao-Ung, Skarratt, Saunders, Tan, Gu, Fuller, Britton, Petrou, Wiley (CR100) 2006; 281
Chen, Yang, Jiang, Jiang (CR35) 2014; 142
Solle, Labasi, Perregaux, Stam, Petrushova, Koller, Griffiths, Gabel (CR89) 2001; 276
Jørgensen, Husted, Skarratt, Stokes, Tofteng, Kvist, Jensen, Eiken, Brixen, Fuller, Clifton-Bligh, Gartland, Schwarz, Langdahl, Wiley (CR77) 2012; 20
Li, Thompson, Paralkar (CR82) 2007; 31
Giuliani, Colognesi, Ricco, Roncato, Capece, Amoroso, Wang, De Marchi, Gartland, Di Virgilio, Adinolfi (CR70) 2014; 9
Orriss, Key, Hajjawi, Arnett (CR73) 2013; 8
Okumura, Shiba, Kubo, Yokoyama (CR114) 2008; 372
Ryan, Shepherd, Leavey, Gao, Grassi, Schnell, Qian, Kersh, Weitzmann, Pacifici (CR24) 2005; 102
von Muecke-Heim, Ries, Urbina, Deussing (CR105) 2021; 271
Sun, Junger, Yuan, Zhang, Bao, Qin, Wang, Tan, Qi, Zhu, Zhang, Yu (CR64) 2013; 31
Panupinthu, Rogers, Zhao, Solano-Flores, Possmayer, Sims, Dixon (CR68) 2008; 181
Ke, Qi, Weidema, Zhang, Panupinthu, Crawford, Grasser, Paralkar, Li, Audoly, Gabel, Jee, Dixon, Sims, Thompson (CR69) 2003; 17
Zhang, Li, Peng, Zhao (CR42) 2019; 41
Bratengeier, Bakker, Fahlgren (CR113) 2019; 234
Wu, Fu, Gu, Wei, Ma, Wu (CR16) 2020; 245
Agrawal, Buckley, Bowers, Furber, Gallagher, Gartland (CR52) 2010; 6
Yoshida, Oida, Kobayashi, Maruyama, Tanaka, Katayama, Yamaguchi, Segi, Tsuboyama, Matsushita, Ito, Ito, Sugimoto, Ushikubi, Ohuchida, Kondo, Nakamura, Narumiya (CR83) 2002; 99
Huang, Xie, Illes, Di Virgilio, Ulrich, Semyanov, Verkhratsky, Sperlagh, Yu, Huang, Tang (CR54) 2021; 6
Matsumoto, Endo (CR91) 2021; 39
Schultz, Wolf (CR4) 2019; 44
Mazzaferro, Cianciolo, De Pascalis, Guglielmo, Urena Torres, Bover, Tartaglione, Pasquali, La Manna (CR8) 2018; 33
Minciullo, Catalano, Mandraffino, Casciaro, Crucitti, Maltese, Morabito, Lasco, Gangemi, Basile (CR33) 2016; 64
Lemoli, Ferrari, Fogli, Rossi, Pizzirani, Forchap, Chiozzi, Vaselli, Bertolini, Foutz, Aluigi, Baccarani, Di Virgilio (CR49) 2004; 104
Orriss, Syberg, Wang, Robaye, Gartland, Jorgensen, Arnett, Boeynaems (CR111) 2011; 1
Kvist, Schwarz, Jørgensen (CR28) 2014; 2014
Orriss, Key, Brandao-Burch, Patel, Burnstock, Arnett (CR79) 2012; 51
Kimble, Matayoshi, Vannice, Kung, Williams, Pacifici (CR26) 1995; 136
Agrawal, Gartland (CR44) 2015; 54
Crandall, Ensrud (CR3) 2020; 323
Adinolfi, Giuliani, De Marchi, Pegoraro, Orioli, Di Virgilio (CR10) 2018; 151
Wang, Gong, Liu, Rao, Li, He, Nie, Wang, Zhong, Xue, Wang, Zhao, Zhou, Ding, Tu, Yang, Xiong, Liang, Xu (CR21) 2018; 36
Xu, He, Wang, Li, Xia, Tan, Chen (CR106) 2019; 10
Gartland, Skarratt, Hocking, Parsons, Stokes, Jørgensen, Fraser, Reid, Gallagher, Wiley (CR97) 2012; 20
Pacifici, Brown, Puscheck, Friedrich, Slatopolsky, Maggio, McCracken, Avioli (CR23) 1991; 88
Pietschmann, Mechtcheriakova, Meshcheryakova, Föger-Samwald, Ellinger (CR34) 2016; 62
Kanazawa, Yamaguchi, Yamamoto, Sugimoto (CR7) 2010; 28
Gachet, Hechler (CR43) 2020; 40
Grol, Zelner, Dixon (CR71) 2012; 302
CR109
GC Macedo (9836_CR45) 2008; 180
RM Lemoli (9836_CR49) 2004; 104
H Okumura (9836_CR114) 2008; 372
JF Hiken (9836_CR55) 2004; 287
P Chotiyarnwong (9836_CR5) 2020; 16
F Di Virgilio (9836_CR87) 2017; 47
Y Chen (9836_CR110) 2018; 1
E Adinolfi (9836_CR10) 2018; 151
9836_CR2
K Schultz (9836_CR4) 2019; 44
T Matsumoto (9836_CR91) 2021; 39
P Habib (9836_CR19) 2018; 178
J Li (9836_CR81) 2005; 280
G Biver (9836_CR62) 2013; 31
A Hoebertz (9836_CR56) 2000; 27
P Illes (9836_CR104) 2021; 178
P Eikelenboom (9836_CR30) 2010; 7
A Salminen (9836_CR37) 2012; 4
P Pellanda (9836_CR31) 2021; 70
P D'Amelio (9836_CR22) 2008; 43
B Zhang (9836_CR78) 2018; 14
BJ Gu (9836_CR101) 2001; 276
Y Dong (9836_CR14) 2020; 125
Y Ma (9836_CR92) 2019; 383
M Solle (9836_CR89) 2001; 276
MW Grol (9836_CR71) 2012; 302
NR Jørgensen (9836_CR77) 2012; 20
MS Morrison (9836_CR60) 1998; 511
W Xiao (9836_CR20) 2019; 22
Z Huang (9836_CR54) 2021; 6
L Zhou (9836_CR94) 2009; 5
MW Grol (9836_CR47) 2009; 5
S Mazzaferro (9836_CR8) 2018; 33
E Nakamura (9836_CR67) 2000; 279
I Varley (9836_CR102) 2018; 108
TH Ambrosi (9836_CR39) 2021; 597
C Gachet (9836_CR43) 2020; 40
TM Kvist (9836_CR48) 2015; 23
P Pietschmann (9836_CR34) 2016; 62
LB Husted (9836_CR96) 2013; 24
S Cenci (9836_CR25) 2000; 106
MR Ryan (9836_CR24) 2005; 102
LN Naemsch (9836_CR57) 2001; 276
JP David (9836_CR27) 2007; 95
M Mishto (9836_CR29) 2003; 2
J Zhang (9836_CR108) 2013; 39
M Li (9836_CR82) 2007; 31
A Gartland (9836_CR46) 2001; 16
DC Genetos (9836_CR76) 2005; 20
I Kanazawa (9836_CR7) 2010; 28
A Agrawal (9836_CR12) 2021; 187
K Chen (9836_CR35) 2014; 142
P Gratal (9836_CR85) 2020; 28
V Baldini (9836_CR9) 2005; 28
K Yoshida (9836_CR83) 2002; 99
AN Shemon (9836_CR100) 2006; 281
I Varley (9836_CR116) 2016; 12
A Gartland (9836_CR53) 2003; 73
A Gartland (9836_CR97) 2012; 20
IA von Muecke-Heim (9836_CR105) 2021; 271
IR Orriss (9836_CR75) 2007; 148
H Wang (9836_CR21) 2018; 36
HG Raterman (9836_CR6) 2020; 21
A Brandao-Burch (9836_CR59) 2012; 19
A Wesselius (9836_CR41) 2011; 1
XY Xu (9836_CR106) 2019; 10
DM Knapik (9836_CR112) 2014; 20
IR Orriss (9836_CR79) 2012; 51
PP Cherian (9836_CR84) 2005; 16
D Du (9836_CR18) 2018; 117
TM Kvist (9836_CR28) 2014; 2014
C Bratengeier (9836_CR113) 2019; 234
NR Jørgensen (9836_CR58) 2002; 277
I Orriss (9836_CR111) 2011; 1
N Panupinthu (9836_CR68) 2008; 181
A Agrawal (9836_CR44) 2015; 54
IY Karkache (9836_CR80) 2021; 1
A Wesselius (9836_CR99) 2013; 24
G Burnstock (9836_CR13) 2013; 9
D Sharma (9836_CR1) 2018; 110
N Zippel (9836_CR63) 2012; 21
A Agrawal (9836_CR52) 2010; 6
Y Ma (9836_CR15) 2021; 5
X Liu (9836_CR98) 2018; 25
Y Matsushita (9836_CR38) 2020; 18
C Guo (9836_CR103) 2007; 72
IR Orriss (9836_CR73) 2013; 8
Q Sun (9836_CR88) 2016; 100
Y Zhang (9836_CR42) 2019; 41
RB Kimble (9836_CR26) 1995; 136
J Li (9836_CR115) 2009; 84
L Wang (9836_CR50) 2004; 3
N Panupinthu (9836_CR72) 2007; 282
IR Orriss (9836_CR66) 2006; 39
A Surprenant (9836_CR61) 1996; 272
DT Pournara (9836_CR107) 2020; 15
D Liu (9836_CR74) 2008; 42
TF Tedder (9836_CR90) 1985; 135
JB Noronha-Matos (9836_CR65) 2014; 28
AL Giuliani (9836_CR70) 2014; 9
CM Barbosa (9836_CR51) 2011; 2
HZ Ke (9836_CR69) 2003; 17
V Pierrefite-Carle (9836_CR36) 2015; 24
CJ Crandall (9836_CR3) 2020; 323
D Sun (9836_CR64) 2013; 31
9836_CR86
W Wu (9836_CR16) 2020; 245
J Lu (9836_CR17) 2020; 24
NR Jørgensen (9836_CR11) 2019; 47
9836_CR109
E De Marchi (9836_CR93) 2016; 104
MB Greenblatt (9836_CR40) 2021; 597
D Zeng (9836_CR95) 2019; 234
R Pacifici (9836_CR23) 1991; 88
PL Minciullo (9836_CR33) 2016; 64
C Franceschi (9836_CR32) 2018; 14
References_xml – volume: 125
  start-page: 110010
  year: 2020
  ident: CR14
  article-title: P2X7 receptor acts as an efficient drug target in regulating bone metabolism system
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2020.110010
– volume: 21
  start-page: 884
  issue: 6
  year: 2012
  end-page: 900
  ident: CR63
  article-title: Purinergic receptors influence the differentiation of human mesenchymal stem cells
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2010.0576
– volume: 39
  start-page: 610
  issue: 4
  year: 2013
  end-page: 618
  ident: CR108
  article-title: Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors
  publication-title: Burns
  doi: 10.1016/j.burns.2012.08.013
– volume: 28
  start-page: 5208
  issue: 12
  year: 2014
  end-page: 5222
  ident: CR65
  article-title: P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow-derived mesenchymal stem cells
  publication-title: FASEB J
  doi: 10.1096/fj.14-257923
– volume: 72
  start-page: 1447
  issue: 6
  year: 2007
  end-page: 1456
  ident: CR103
  article-title: Evidence for functional P2X4/P2X7 heteromeric receptors
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.107.035980
– volume: 31
  start-page: 2747
  issue: 12
  year: 2013
  end-page: 2758
  ident: CR62
  article-title: Role of the P2Y13 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes
  publication-title: Stem Cells
  doi: 10.1002/stem.1411
– volume: 9
  start-page: e107224
  issue: 9
  year: 2014
  ident: CR70
  article-title: Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0107224
– volume: 20
  start-page: 675
  issue: 6
  year: 2012
  end-page: 681
  ident: CR77
  article-title: Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2011.253
– volume: 383
  start-page: 111555
  issue: 2
  year: 2019
  ident: CR92
  article-title: The effect of P2X7R-mediated Ca2+ signaling in OPG-induced osteoclasts adhesive structure damage
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2019.111555
– volume: 16
  start-page: 437
  issue: 8
  year: 2020
  end-page: 447
  ident: CR5
  article-title: Pathogenesis of glucocorticoid-induced osteoporosisand options for treatment
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-020-0341-0
– volume: 14
  start-page: 492
  year: 2018
  end-page: 498
  ident: CR78
  article-title: Mechanically induced autophagy is associated with ATP metabolism and cellular viability in osteocytes in vitro
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2017.10.021
– volume: 511
  start-page: 495
  issue: 2
  year: 1998
  end-page: 500
  ident: CR60
  article-title: ATP is a potent stimulator of the activation and formation of rodent osteoclasts
  publication-title: J Physiol
  doi: 10.1111/j.1469-7793.1998.495bh.x
– volume: 25
  start-page: 329
  issue: 3
  year: 2018
  end-page: 335
  ident: CR98
  article-title: Purinergic P2X7 receptor functional genetic polymorphisms are associated with the susceptibility to obesity in Chinese postmenopausal women
  publication-title: Menopause
  doi: 10.1097/GME.0000000000000991
– volume: 104
  start-page: 39
  year: 2016
  end-page: 79
  ident: CR93
  article-title: P2X7 receptor as a therapeutic target
  publication-title: Adv Protein Chem Struct Biol
  doi: 10.1016/bs.apcsb.2015.11.004
– volume: 135
  start-page: 1786
  issue: 3
  year: 1985
  end-page: 1791
  ident: CR90
  article-title: Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases
  publication-title: J Immunol
  doi: 10.4049/jimmunol.135.3.1786
– volume: 272
  start-page: 735
  issue: 5262
  year: 1996
  end-page: 8
  ident: CR61
  article-title: The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
  publication-title: Science
  doi: 10.1126/science.272.5262.735
– volume: 276
  start-page: 39107
  issue: 42
  year: 2001
  end-page: 14
  ident: CR57
  article-title: Activity-dependent development of P2X7 current and Ca2+ entry in rabbit osteoclasts
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M105881200
– volume: 84
  start-page: 405
  issue: 5
  year: 2009
  end-page: 412
  ident: CR115
  article-title: P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair
  publication-title: Calcif Tissue Int
  doi: 10.1007/s00223-009-9237-7
– volume: 276
  start-page: 125
  issue: 1
  year: 2001
  end-page: 32
  ident: CR89
  article-title: Altered cytokine production in mice lacking P2X(7) receptors
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M006781200
– volume: 117
  start-page: 161
  year: 2018
  end-page: 170
  ident: CR18
  article-title: TNF-α suppresses osteogenic differentiation of MSCs by accelerating P2Y2 receptor in estrogen-deficiency induced osteoporosis
  publication-title: Bone
  doi: 10.1016/j.bone.2018.09.012
– volume: 136
  start-page: 3054
  issue: 7
  year: 1995
  end-page: 3061
  ident: CR26
  article-title: Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period
  publication-title: Endocrinology
  doi: 10.1210/endo.136.7.7789332
– volume: 24
  start-page: 1235
  issue: 4
  year: 2013
  end-page: 1246
  ident: CR99
  article-title: Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients
  publication-title: Osteoporos Int
  doi: 10.1007/s00198-012-2059-x
– volume: 10
  start-page: 20
  issue: 1
  year: 2019
  ident: CR106
  article-title: Role of the P2X7 receptor in inflammation-mediated changes in the osteogenesis of periodontal ligament stem cells
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-1253-y
– volume: 1
  start-page: 145362
  issue: 771
  year: 2021
  ident: CR80
  article-title: Serine/threonine phosphatases in osteoclastogenesis and bone resorption
  publication-title: Gene
  doi: 10.1016/j.gene.2020.145362
– volume: 20
  start-page: 970
  issue: 6
  year: 2014
  end-page: 85
  ident: CR112
  article-title: Mechanosignaling in bone health, trauma and inflammation
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5467
– volume: 99
  start-page: 4580
  issue: 7
  year: 2002
  end-page: 5
  ident: CR83
  article-title: Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.062053399
– volume: 22
  start-page: 498
  issue: 5
  year: 2019
  end-page: 506
  ident: CR20
  article-title: Association of P2X7R gene with serum lipid profiles in Chinese postmenopausal women with osteoporosis
  publication-title: Climacteric
  doi: 10.1080/13697137.2019.1604654
– volume: 180
  start-page: 1080
  issue: 2
  year: 2008
  end-page: 7
  ident: CR45
  article-title: Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.2.1080
– volume: 1
  start-page: 1038
  issue: 3
  year: 2011
  end-page: 1046
  ident: CR111
  article-title: Bone phenotypes of P2 receptor knockout mice
  publication-title: Front Biosci (Schol Ed)
  doi: 10.2741/208
– volume: 23
  start-page: 145
  issue: 7
  year: 2015
  end-page: 151
  ident: CR48
  article-title: The role of the P2X7 receptor on bone loss in a mouse model of inflammation-mediated osteoporosis
  publication-title: Bone Rep
  doi: 10.1016/j.bonr.2015.09.003
– ident: CR109
– volume: 73
  start-page: 361
  issue: 4
  year: 2003
  end-page: 369
  ident: CR53
  article-title: Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro
  publication-title: Calcif Tissue Int
  doi: 10.1007/s00223-002-2098-y
– volume: 1
  start-page: 2572
  issue: 16
  year: 2011
  end-page: 2585
  ident: CR41
  article-title: Role of purinergic receptor polymorphisms in human bone
  publication-title: Front Biosci (Landmark Ed)
  doi: 10.2741/3873
– volume: 28
  start-page: 506
  issue: 7
  year: 2020
  ident: CR85
  article-title: Purinergic system signaling in metainflammation-associated osteoarthritis
  publication-title: Front Med (Lausanne)
  doi: 10.3389/fmed.2020.00506
– volume: 187
  start-page: 114425
  year: 2021
  ident: CR12
  article-title: Extracellular purines and bone homeostasis
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2021.114425
– volume: 234
  start-page: 13057
  issue: 8
  year: 2019
  end-page: 13067
  ident: CR113
  article-title: Mechanical loading releases osteoclastogenesis-modulating factors through stimulation of the P2X7 receptor in hematopoietic progenitor cells
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27976
– ident: CR86
– volume: 14
  start-page: 576
  issue: 10
  year: 2018
  end-page: 590
  ident: CR32
  article-title: Inflammaging: a new immune-metabolic viewpoint for age-related diseases
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-018-0059-4
– volume: 31
  start-page: 1170
  issue: 6
  year: 2013
  end-page: 1180
  ident: CR64
  article-title: Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors
  publication-title: Stem Cells
  doi: 10.1002/stem.1356
– volume: 40
  start-page: 145
  issue: 2
  year: 2020
  end-page: 152
  ident: CR43
  article-title: Platelet purinergic receptors in thrombosis and inflammation
  publication-title: Hamostaseologie
  doi: 10.1055/a-1113-0711
– volume: 24
  start-page: 206
  issue: Pt B
  year: 2015
  end-page: 217
  ident: CR36
  article-title: Autophagy in bone: self-eating to stay in balance
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2015.08.004
– volume: 28
  start-page: 69
  issue: 10 Suppl
  year: 2005
  end-page: 72
  ident: CR9
  article-title: Cardiovascular disease and osteoporosis
  publication-title: J Endocrinol Invest
– volume: 110
  start-page: 1
  year: 2018
  end-page: 10
  ident: CR1
  article-title: The effects of estrogen deficiency on cortical bone microporosity and mineralization
  publication-title: Bone
  doi: 10.1016/j.bone.2018.01.019
– volume: 5
  start-page: 205
  issue: 2
  year: 2009
  end-page: 221
  ident: CR47
  article-title: Expression, signaling, and function of P2X7 receptors in bone
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-009-9139-1
– volume: 282
  start-page: 3403
  issue: 5
  year: 2007
  end-page: 12
  ident: CR72
  article-title: P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway in Panupinthu N, Zhao L olving lysophosphatidic acid
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M605620200
– volume: 8
  start-page: e69057
  issue: 7
  year: 2013
  ident: CR73
  article-title: Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0069057
– volume: 151
  start-page: 234
  year: 2018
  end-page: 244
  ident: CR10
  article-title: The P2X7 receptor: a main player in inflammation
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2017.12.021
– volume: 16
  start-page: 3100
  issue: 7
  year: 2005
  end-page: 3106
  ident: CR84
  article-title: Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e04-10-0912
– volume: 100
  start-page: 961
  issue: 5
  year: 2016
  end-page: 967
  ident: CR88
  article-title: Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.3MR0516-224R
– volume: 148
  start-page: 4208
  issue: 9
  year: 2007
  end-page: 4216
  ident: CR75
  article-title: Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate
  publication-title: Endocrinology
  doi: 10.1210/en.2007-0066
– volume: 281
  start-page: 2079
  issue: 4
  year: 2006
  end-page: 86
  ident: CR100
  article-title: A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M507816200
– volume: 287
  start-page: C403
  issue: 2
  year: 2004
  end-page: C412
  ident: CR55
  article-title: ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00361.2003
– volume: 5
  start-page: 124251
  issue: 405
  year: 2021
  ident: CR15
  article-title: The effect of P2X7 on cadmium-induced osteoporosis in mice
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2020.124251
– volume: 279
  start-page: C510
  issue: 2
  year: 2000
  end-page: C519
  ident: CR67
  article-title: ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.2000.279.2.C510
– volume: 234
  start-page: 2095
  issue: 3
  year: 2019
  end-page: 2103
  ident: CR95
  article-title: P2X7, a critical regulator and potential target for bone and joint diseases
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27544
– volume: 47
  start-page: 15
  issue: 1
  year: 2017
  end-page: 31
  ident: CR87
  article-title: The P2X7 receptor in infection and inflammation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.06.020
– volume: 276
  start-page: 11135
  issue: 14
  year: 2001
  end-page: 42
  ident: CR101
  article-title: A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M010353200
– volume: 12
  start-page: 103
  issue: 1
  year: 2016
  end-page: 113
  ident: CR116
  article-title: Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-016-9495-6
– volume: 62
  start-page: 128
  issue: 2
  year: 2016
  end-page: 137
  ident: CR34
  article-title: Immunology of osteoporosis: a mini-review
  publication-title: Gerontology
  doi: 10.1159/000431091
– volume: 42
  start-page: 644
  issue: 4
  year: 2008
  end-page: 652
  ident: CR74
  article-title: Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts
  publication-title: Bone
  doi: 10.1016/j.bone.2007.09.058
– volume: 104
  start-page: 1662
  issue: 6
  year: 2004
  end-page: 1670
  ident: CR49
  article-title: Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo
  publication-title: Blood
  doi: 10.1182/blood-2004-03-0834
– volume: 15
  start-page: 2530
  issue: 24
  year: 2020
  end-page: 2543
  ident: CR107
  article-title: Design, Synthesis, and in vitro evaluation of P2X7 antagonists
  publication-title: ChemMedChem
  doi: 10.1002/cmdc.202000303
– volume: 6
  start-page: 162
  issue: 1
  year: 2021
  ident: CR54
  article-title: From purines to purinergic signalling: molecular functions and human diseases
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-021-00553-z
– volume: 43
  start-page: 92
  issue: 1
  year: 2008
  end-page: 100
  ident: CR22
  article-title: Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis
  publication-title: Bone
  doi: 10.1016/j.bone.2008.02.017
– volume: 16
  start-page: 846
  issue: 5
  year: 2001
  end-page: 856
  ident: CR46
  article-title: Expression of a P2X7 receptor by a subpopulation of human osteoblasts
  publication-title: J Bone Miner Res
  doi: 10.1359/jbmr.2001.16.5.846
– volume: 41
  start-page: 955
  issue: 05
  year: 2019
  end-page: 960
  ident: CR42
  article-title: P2x7 receptor and inflammation-related diseases
  publication-title: Chin J Cell Biol
– volume: 280
  start-page: 42952
  issue: 52
  year: 2005
  end-page: 9
  ident: CR81
  article-title: The P2X7 nucleotide receptor mediates skeletal mechanotransduction
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M506415200
– volume: 95
  start-page: 149
  year: 2007
  end-page: 165
  ident: CR27
  article-title: Osteoimmunology: a view from the bone
  publication-title: Adv Immunol
  doi: 10.1016/S0065-2776(07)95005-1
– volume: 24
  start-page: 949
  issue: 3
  year: 2013
  end-page: 959
  ident: CR96
  article-title: Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis
  publication-title: Osteoporos Int
  doi: 10.1007/s00198-012-2035-5
– volume: 51
  start-page: 389
  issue: 3
  year: 2012
  end-page: 400
  ident: CR79
  article-title: The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: the role of p2x receptors
  publication-title: Bone
  doi: 10.1016/j.bone.2012.06.013
– volume: 5
  start-page: 409
  issue: 3
  year: 2009
  end-page: 426
  ident: CR94
  article-title: Regulation of P2X(7) gene transcription
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-009-9167-x
– volume: 271
  start-page: 1343
  issue: 7
  year: 2021
  end-page: 1358
  ident: CR105
  article-title: P2X7R antagonists in chronic stress-based depression models: a review
  publication-title: Eur Arch Psychiatry Clin Neurosci
  doi: 10.1007/s00406-021-01306-3
– volume: 323
  start-page: 367
  issue: 4
  year: 2020
  end-page: 368
  ident: CR3
  article-title: Osteoporosis screening in younger postmenopausal women
  publication-title: JAMA
  doi: 10.1001/jama.2019.18343
– volume: 17
  start-page: 1356
  issue: 7
  year: 2003
  end-page: 1367
  ident: CR69
  article-title: Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
  publication-title: Mol Endocrinol
  doi: 10.1210/me.2003-0021
– volume: 597
  start-page: 256
  issue: 7875
  year: 2021
  end-page: 262
  ident: CR39
  article-title: Aged skeletal stem cells generate an inflammatory degenerative niche
  publication-title: Nature
  doi: 10.1038/s41586-021-03795-7
– volume: 44
  start-page: 240
  issue: 3
  year: 2019
  end-page: 243
  ident: CR4
  article-title: Emerging technologies in osteoporosis diagnosis
  publication-title: J Hand Surg Am
  doi: 10.1016/j.jhsa.2018.07.006
– volume: 3
  start-page: 16
  issue: 5
  year: 2004
  ident: CR50
  article-title: P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells
  publication-title: BMC Immunol
  doi: 10.1186/1471-2172-5-16
– volume: 24
  start-page: 14316
  issue: 24
  year: 2020
  end-page: 14324
  ident: CR17
  article-title: Tumour necrosis factor-α promotes BMHSC differentiation by increasing P2X7 receptor in oestrogen-deficient osteoporosis
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.16048
– volume: 64
  start-page: 111
  issue: 2
  year: 2016
  end-page: 126
  ident: CR33
  article-title: Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity
  publication-title: Arch Immunol Ther Exp (Warsz)
  doi: 10.1007/s00005-015-0377-3
– volume: 302
  start-page: E561
  issue: 5
  year: 2012
  end-page: 75
  ident: CR71
  article-title: P2X7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00209.2011
– volume: 181
  start-page: 859
  issue: 5
  year: 2008
  end-page: 71
  ident: CR68
  article-title: P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200708037
– volume: 31
  start-page: 767
  issue: 6
  year: 2007
  end-page: 772
  ident: CR82
  article-title: Prostaglandin E(2) receptors in bone formation
  publication-title: Int Orthop
  doi: 10.1007/s00264-007-0406-x
– volume: 20
  start-page: 559
  issue: 5
  year: 2012
  end-page: 564
  ident: CR97
  article-title: Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2011.245
– volume: 70
  start-page: 48
  year: 2021
  end-page: 55
  ident: CR31
  article-title: Understanding the impact of age-related changes in the gut microbiome on chronic diseases and the prospect of elderly-specific dietary interventions
  publication-title: Curr Opin Biotechnol
  doi: 10.1016/j.copbio.2020.11.001
– volume: 245
  start-page: 141
  issue: 1
  year: 2020
  end-page: 153
  ident: CR16
  article-title: JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells
  publication-title: J Endocrinol
  doi: 10.1530/JOE-19-0518
– volume: 106
  start-page: 1229
  issue: 10
  year: 2000
  end-page: 1237
  ident: CR25
  article-title: Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
  publication-title: J Clin Invest
  doi: 10.1172/JCI11066
– volume: 178
  start-page: 340
  year: 2018
  end-page: 347
  ident: CR19
  article-title: Estrogen serum concentration affects blood immune cell composition and polarization in human females under controlled ovarian stimulation
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2018.02.005
– volume: 39
  start-page: 91
  issue: 1
  year: 2021
  end-page: 105
  ident: CR91
  article-title: RANKL as a target for the treatment of osteoporosis
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-020-01153-7
– volume: 33
  start-page: 2092
  issue: 12
  year: 2018
  end-page: 2100
  ident: CR8
  article-title: Bone, inflammation and the bone marrow niche in chronic kidney disease: what do we know?
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/gfy115
– volume: 47
  start-page: 97
  year: 2019
  end-page: 101
  ident: CR11
  article-title: Role of the purinergic P2X receptors in osteoclast pathophysiology
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2019.02.013
– volume: 102
  start-page: 16735
  issue: 46
  year: 2005
  end-page: 40
  ident: CR24
  article-title: An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0505168102
– volume: 54
  start-page: R75
  issue: 2
  year: 2015
  end-page: 88
  ident: CR44
  article-title: P2X7 receptors: role in bone cell formation and function
  publication-title: J Mol Endocrinol
  doi: 10.1530/JME-14-0226
– volume: 2
  start-page: e165
  issue: 6
  year: 2011
  ident: CR51
  article-title: Differentiation of hematopoietic stem cell and myeloid populations by ATP is modulated by cytokines
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2011.49
– ident: CR2
– volume: 27
  start-page: 503
  issue: 4
  year: 2000
  end-page: 510
  ident: CR56
  article-title: Expression of P2 receptors in bone and cultured bone cells
  publication-title: Bone
  doi: 10.1016/s8756-3282(00)00351-3
– volume: 88
  start-page: 5134
  issue: 12
  year: 1991
  end-page: 8
  ident: CR23
  article-title: Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.88.12.5134
– volume: 2014
  start-page: 954530
  issue: 16
  year: 2014
  ident: CR28
  article-title: The P2X7 receptor: a key player in immune-mediated bone loss?
  publication-title: Sci World J
  doi: 10.1155/2014/954530
– volume: 6
  start-page: 307
  issue: 3
  year: 2010
  end-page: 315
  ident: CR52
  article-title: The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-010-9181-z
– volume: 9
  start-page: 541
  issue: 4
  year: 2013
  end-page: 572
  ident: CR13
  article-title: Purinergic signalling in the musculoskeletal system
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-013-9381-4
– volume: 597
  start-page: 182
  issue: 7875
  year: 2021
  end-page: 183
  ident: CR40
  article-title: A stem-cell basis for skeletal ageing
  publication-title: Nature
  doi: 10.1038/d41586-021-02118-0
– volume: 108
  start-page: 179
  year: 2018
  end-page: 185
  ident: CR102
  article-title: SNPs in the vicinity of P2X7R, RANK/RANKL/OPG and Wnt signalling pathways and their association with bone phenotypes in academy footballers
  publication-title: Bone
  doi: 10.1016/j.bone.2018.01.007
– volume: 39
  start-page: 300
  issue: 2
  year: 2006
  end-page: 309
  ident: CR66
  article-title: Osteoblast responses to nucleotides increase during differentiation
  publication-title: Bone
  doi: 10.1016/j.bone.2006.02.063
– volume: 4
  start-page: 166
  issue: 3
  year: 2012
  end-page: 75
  ident: CR37
  article-title: Inflammaging: disturbed interplay between autophagy and inflammasomes
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.100444
– volume: 7
  start-page: 38
  issue: 1–3
  year: 2010
  end-page: 41
  ident: CR30
  article-title: Neuroinflammation — an early event in both the history and pathogenesis of Alzheimer's disease
  publication-title: Neurodegener Dis
  doi: 10.1159/000283480
– volume: 178
  start-page: 489
  issue: 3
  year: 2021
  end-page: 514
  ident: CR104
  article-title: Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.15299
– volume: 20
  start-page: 41
  issue: 1
  year: 2005
  end-page: 49
  ident: CR76
  article-title: Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts
  publication-title: J Bone Miner Res
  doi: 10.1359/JBMR.041009
– volume: 277
  start-page: 7574
  issue: 9
  year: 2002
  end-page: 80
  ident: CR58
  article-title: Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M104608200
– volume: 36
  start-page: 488
  issue: 4
  year: 2018
  end-page: 497
  ident: CR21
  article-title: Genetic interaction of purinergic P2X7 receptor and ER-α polymorphisms in susceptibility to osteoporosis in Chinese postmenopausal women
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-017-0862-3
– volume: 18
  start-page: 189
  issue: 3
  year: 2020
  end-page: 198
  ident: CR38
  article-title: Skeletal stem cells for bone development and repair: diversity matters
  publication-title: Curr Osteoporos Rep
  doi: 10.1007/s11914-020-00572-9
– volume: 19
  start-page: 41
  issue: 3
  year: 2012
  ident: CR59
  article-title: The P2X7 receptor is an important regulator of extracellular ATP levels
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2012.00041
– volume: 372
  start-page: 486
  issue: 3
  year: 2008
  end-page: 90
  ident: CR114
  article-title: P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts
  publication-title: Biochem Biophys Res Commun.
  doi: 10.1016/j.bbrc.2008.05.066
– volume: 28
  start-page: 554
  issue: 5
  year: 2010
  end-page: 560
  ident: CR7
  article-title: Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-010-0160-9
– volume: 2
  start-page: 419
  issue: 4
  year: 2003
  end-page: 432
  ident: CR29
  article-title: Immunoproteasomes and immunosenescence
  publication-title: Ageing Res Rev
  doi: 10.1016/s1568-1637(03)00030-8
– volume: 142
  start-page: 285
  issue: 3
  year: 2014
  end-page: 295
  ident: CR35
  article-title: Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population
  publication-title: Histochem Cell Biol
  doi: 10.1007/s00418-014-1194-1
– volume: 1
  start-page: 305
  issue: 208
  year: 2018
  end-page: 314
  ident: CR110
  article-title: Inhibitory effect of vanillin on RANKL-induced osteoclast formation and function through activating mitochondrial-dependent apoptosis signaling pathway
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2018.07.048
– volume: 21
  start-page: 1725
  issue: 14
  year: 2020
  end-page: 1737
  ident: CR6
  article-title: Osteoporosis in patients with rheumatoid arthritis: an update in epidemiology, pathogenesis, and fracture prevention
  publication-title: Expert Opin Pharmacother
  doi: 10.1080/14656566.2020.1787381
– volume: 1
  start-page: 145362
  issue: 771
  year: 2021
  ident: 9836_CR80
  publication-title: Gene
  doi: 10.1016/j.gene.2020.145362
– volume: 62
  start-page: 128
  issue: 2
  year: 2016
  ident: 9836_CR34
  publication-title: Gerontology
  doi: 10.1159/000431091
– volume: 18
  start-page: 189
  issue: 3
  year: 2020
  ident: 9836_CR38
  publication-title: Curr Osteoporos Rep
  doi: 10.1007/s11914-020-00572-9
– volume: 47
  start-page: 97
  year: 2019
  ident: 9836_CR11
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2019.02.013
– volume: 12
  start-page: 103
  issue: 1
  year: 2016
  ident: 9836_CR116
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-016-9495-6
– volume: 5
  start-page: 124251
  issue: 405
  year: 2021
  ident: 9836_CR15
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2020.124251
– volume: 28
  start-page: 506
  issue: 7
  year: 2020
  ident: 9836_CR85
  publication-title: Front Med (Lausanne)
  doi: 10.3389/fmed.2020.00506
– volume: 271
  start-page: 1343
  issue: 7
  year: 2021
  ident: 9836_CR105
  publication-title: Eur Arch Psychiatry Clin Neurosci
  doi: 10.1007/s00406-021-01306-3
– volume: 2014
  start-page: 954530
  issue: 16
  year: 2014
  ident: 9836_CR28
  publication-title: Sci World J
  doi: 10.1155/2014/954530
– volume: 42
  start-page: 644
  issue: 4
  year: 2008
  ident: 9836_CR74
  publication-title: Bone
  doi: 10.1016/j.bone.2007.09.058
– volume: 8
  start-page: e69057
  issue: 7
  year: 2013
  ident: 9836_CR73
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0069057
– volume: 14
  start-page: 576
  issue: 10
  year: 2018
  ident: 9836_CR32
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-018-0059-4
– volume: 10
  start-page: 20
  issue: 1
  year: 2019
  ident: 9836_CR106
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-1253-y
– volume: 28
  start-page: 69
  issue: 10 Suppl
  year: 2005
  ident: 9836_CR9
  publication-title: J Endocrinol Invest
– volume: 102
  start-page: 16735
  issue: 46
  year: 2005
  ident: 9836_CR24
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0505168102
– volume: 9
  start-page: e107224
  issue: 9
  year: 2014
  ident: 9836_CR70
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0107224
– volume: 142
  start-page: 285
  issue: 3
  year: 2014
  ident: 9836_CR35
  publication-title: Histochem Cell Biol
  doi: 10.1007/s00418-014-1194-1
– volume: 6
  start-page: 162
  issue: 1
  year: 2021
  ident: 9836_CR54
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-021-00553-z
– volume: 234
  start-page: 13057
  issue: 8
  year: 2019
  ident: 9836_CR113
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27976
– volume: 19
  start-page: 41
  issue: 3
  year: 2012
  ident: 9836_CR59
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2012.00041
– volume: 100
  start-page: 961
  issue: 5
  year: 2016
  ident: 9836_CR88
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.3MR0516-224R
– volume: 277
  start-page: 7574
  issue: 9
  year: 2002
  ident: 9836_CR58
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M104608200
– volume: 181
  start-page: 859
  issue: 5
  year: 2008
  ident: 9836_CR68
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200708037
– volume: 1
  start-page: 2572
  issue: 16
  year: 2011
  ident: 9836_CR41
  publication-title: Front Biosci (Landmark Ed)
  doi: 10.2741/3873
– volume: 125
  start-page: 110010
  year: 2020
  ident: 9836_CR14
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2020.110010
– volume: 51
  start-page: 389
  issue: 3
  year: 2012
  ident: 9836_CR79
  publication-title: Bone
  doi: 10.1016/j.bone.2012.06.013
– volume: 178
  start-page: 489
  issue: 3
  year: 2021
  ident: 9836_CR104
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.15299
– volume: 24
  start-page: 949
  issue: 3
  year: 2013
  ident: 9836_CR96
  publication-title: Osteoporos Int
  doi: 10.1007/s00198-012-2035-5
– ident: 9836_CR86
  doi: 10.4049/jimmunol.176.7.3877
– volume: 14
  start-page: 492
  year: 2018
  ident: 9836_CR78
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2017.10.021
– volume: 72
  start-page: 1447
  issue: 6
  year: 2007
  ident: 9836_CR103
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.107.035980
– volume: 383
  start-page: 111555
  issue: 2
  year: 2019
  ident: 9836_CR92
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2019.111555
– volume: 70
  start-page: 48
  year: 2021
  ident: 9836_CR31
  publication-title: Curr Opin Biotechnol
  doi: 10.1016/j.copbio.2020.11.001
– volume: 279
  start-page: C510
  issue: 2
  year: 2000
  ident: 9836_CR67
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.2000.279.2.C510
– volume: 99
  start-page: 4580
  issue: 7
  year: 2002
  ident: 9836_CR83
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.062053399
– volume: 20
  start-page: 675
  issue: 6
  year: 2012
  ident: 9836_CR77
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2011.253
– ident: 9836_CR109
  doi: 10.1155/2021/5556122
– volume: 39
  start-page: 91
  issue: 1
  year: 2021
  ident: 9836_CR91
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-020-01153-7
– volume: 17
  start-page: 1356
  issue: 7
  year: 2003
  ident: 9836_CR69
  publication-title: Mol Endocrinol
  doi: 10.1210/me.2003-0021
– volume: 20
  start-page: 970
  issue: 6
  year: 2014
  ident: 9836_CR112
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5467
– volume: 95
  start-page: 149
  year: 2007
  ident: 9836_CR27
  publication-title: Adv Immunol
  doi: 10.1016/S0065-2776(07)95005-1
– volume: 282
  start-page: 3403
  issue: 5
  year: 2007
  ident: 9836_CR72
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M605620200
– volume: 47
  start-page: 15
  issue: 1
  year: 2017
  ident: 9836_CR87
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.06.020
– volume: 108
  start-page: 179
  year: 2018
  ident: 9836_CR102
  publication-title: Bone
  doi: 10.1016/j.bone.2018.01.007
– volume: 2
  start-page: e165
  issue: 6
  year: 2011
  ident: 9836_CR51
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2011.49
– volume: 64
  start-page: 111
  issue: 2
  year: 2016
  ident: 9836_CR33
  publication-title: Arch Immunol Ther Exp (Warsz)
  doi: 10.1007/s00005-015-0377-3
– volume: 31
  start-page: 1170
  issue: 6
  year: 2013
  ident: 9836_CR64
  publication-title: Stem Cells
  doi: 10.1002/stem.1356
– volume: 280
  start-page: 42952
  issue: 52
  year: 2005
  ident: 9836_CR81
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M506415200
– volume: 25
  start-page: 329
  issue: 3
  year: 2018
  ident: 9836_CR98
  publication-title: Menopause
  doi: 10.1097/GME.0000000000000991
– volume: 597
  start-page: 256
  issue: 7875
  year: 2021
  ident: 9836_CR39
  publication-title: Nature
  doi: 10.1038/s41586-021-03795-7
– volume: 41
  start-page: 955
  issue: 05
  year: 2019
  ident: 9836_CR42
  publication-title: Chin J Cell Biol
– volume: 23
  start-page: 145
  issue: 7
  year: 2015
  ident: 9836_CR48
  publication-title: Bone Rep
  doi: 10.1016/j.bonr.2015.09.003
– volume: 22
  start-page: 498
  issue: 5
  year: 2019
  ident: 9836_CR20
  publication-title: Climacteric
  doi: 10.1080/13697137.2019.1604654
– volume: 36
  start-page: 488
  issue: 4
  year: 2018
  ident: 9836_CR21
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-017-0862-3
– volume: 151
  start-page: 234
  year: 2018
  ident: 9836_CR10
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2017.12.021
– volume: 135
  start-page: 1786
  issue: 3
  year: 1985
  ident: 9836_CR90
  publication-title: J Immunol
  doi: 10.4049/jimmunol.135.3.1786
– volume: 88
  start-page: 5134
  issue: 12
  year: 1991
  ident: 9836_CR23
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.88.12.5134
– volume: 39
  start-page: 610
  issue: 4
  year: 2013
  ident: 9836_CR108
  publication-title: Burns
  doi: 10.1016/j.burns.2012.08.013
– volume: 110
  start-page: 1
  year: 2018
  ident: 9836_CR1
  publication-title: Bone
  doi: 10.1016/j.bone.2018.01.019
– volume: 28
  start-page: 554
  issue: 5
  year: 2010
  ident: 9836_CR7
  publication-title: J Bone Miner Metab
  doi: 10.1007/s00774-010-0160-9
– volume: 104
  start-page: 1662
  issue: 6
  year: 2004
  ident: 9836_CR49
  publication-title: Blood
  doi: 10.1182/blood-2004-03-0834
– volume: 281
  start-page: 2079
  issue: 4
  year: 2006
  ident: 9836_CR100
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M507816200
– volume: 187
  start-page: 114425
  year: 2021
  ident: 9836_CR12
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2021.114425
– volume: 178
  start-page: 340
  year: 2018
  ident: 9836_CR19
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2018.02.005
– volume: 40
  start-page: 145
  issue: 2
  year: 2020
  ident: 9836_CR43
  publication-title: Hamostaseologie
  doi: 10.1055/a-1113-0711
– volume: 276
  start-page: 125
  issue: 1
  year: 2001
  ident: 9836_CR89
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M006781200
– volume: 7
  start-page: 38
  issue: 1–3
  year: 2010
  ident: 9836_CR30
  publication-title: Neurodegener Dis
  doi: 10.1159/000283480
– volume: 54
  start-page: R75
  issue: 2
  year: 2015
  ident: 9836_CR44
  publication-title: J Mol Endocrinol
  doi: 10.1530/JME-14-0226
– volume: 106
  start-page: 1229
  issue: 10
  year: 2000
  ident: 9836_CR25
  publication-title: J Clin Invest
  doi: 10.1172/JCI11066
– volume: 245
  start-page: 141
  issue: 1
  year: 2020
  ident: 9836_CR16
  publication-title: J Endocrinol
  doi: 10.1530/JOE-19-0518
– volume: 2
  start-page: 419
  issue: 4
  year: 2003
  ident: 9836_CR29
  publication-title: Ageing Res Rev
  doi: 10.1016/s1568-1637(03)00030-8
– volume: 148
  start-page: 4208
  issue: 9
  year: 2007
  ident: 9836_CR75
  publication-title: Endocrinology
  doi: 10.1210/en.2007-0066
– volume: 28
  start-page: 5208
  issue: 12
  year: 2014
  ident: 9836_CR65
  publication-title: FASEB J
  doi: 10.1096/fj.14-257923
– volume: 24
  start-page: 206
  issue: Pt B
  year: 2015
  ident: 9836_CR36
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2015.08.004
– volume: 20
  start-page: 41
  issue: 1
  year: 2005
  ident: 9836_CR76
  publication-title: J Bone Miner Res
  doi: 10.1359/JBMR.041009
– volume: 5
  start-page: 409
  issue: 3
  year: 2009
  ident: 9836_CR94
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-009-9167-x
– volume: 1
  start-page: 1038
  issue: 3
  year: 2011
  ident: 9836_CR111
  publication-title: Front Biosci (Schol Ed)
  doi: 10.2741/208
– volume: 180
  start-page: 1080
  issue: 2
  year: 2008
  ident: 9836_CR45
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.2.1080
– volume: 323
  start-page: 367
  issue: 4
  year: 2020
  ident: 9836_CR3
  publication-title: JAMA
  doi: 10.1001/jama.2019.18343
– volume: 6
  start-page: 307
  issue: 3
  year: 2010
  ident: 9836_CR52
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-010-9181-z
– volume: 1
  start-page: 305
  issue: 208
  year: 2018
  ident: 9836_CR110
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2018.07.048
– volume: 16
  start-page: 3100
  issue: 7
  year: 2005
  ident: 9836_CR84
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e04-10-0912
– volume: 27
  start-page: 503
  issue: 4
  year: 2000
  ident: 9836_CR56
  publication-title: Bone
  doi: 10.1016/s8756-3282(00)00351-3
– volume: 31
  start-page: 767
  issue: 6
  year: 2007
  ident: 9836_CR82
  publication-title: Int Orthop
  doi: 10.1007/s00264-007-0406-x
– volume: 15
  start-page: 2530
  issue: 24
  year: 2020
  ident: 9836_CR107
  publication-title: ChemMedChem
  doi: 10.1002/cmdc.202000303
– volume: 597
  start-page: 182
  issue: 7875
  year: 2021
  ident: 9836_CR40
  publication-title: Nature
  doi: 10.1038/d41586-021-02118-0
– volume: 9
  start-page: 541
  issue: 4
  year: 2013
  ident: 9836_CR13
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-013-9381-4
– volume: 276
  start-page: 39107
  issue: 42
  year: 2001
  ident: 9836_CR57
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M105881200
– volume: 43
  start-page: 92
  issue: 1
  year: 2008
  ident: 9836_CR22
  publication-title: Bone
  doi: 10.1016/j.bone.2008.02.017
– volume: 44
  start-page: 240
  issue: 3
  year: 2019
  ident: 9836_CR4
  publication-title: J Hand Surg Am
  doi: 10.1016/j.jhsa.2018.07.006
– volume: 104
  start-page: 39
  year: 2016
  ident: 9836_CR93
  publication-title: Adv Protein Chem Struct Biol
  doi: 10.1016/bs.apcsb.2015.11.004
– volume: 31
  start-page: 2747
  issue: 12
  year: 2013
  ident: 9836_CR62
  publication-title: Stem Cells
  doi: 10.1002/stem.1411
– volume: 511
  start-page: 495
  issue: 2
  year: 1998
  ident: 9836_CR60
  publication-title: J Physiol
  doi: 10.1111/j.1469-7793.1998.495bh.x
– volume: 4
  start-page: 166
  issue: 3
  year: 2012
  ident: 9836_CR37
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.100444
– volume: 84
  start-page: 405
  issue: 5
  year: 2009
  ident: 9836_CR115
  publication-title: Calcif Tissue Int
  doi: 10.1007/s00223-009-9237-7
– volume: 3
  start-page: 16
  issue: 5
  year: 2004
  ident: 9836_CR50
  publication-title: BMC Immunol
  doi: 10.1186/1471-2172-5-16
– volume: 20
  start-page: 559
  issue: 5
  year: 2012
  ident: 9836_CR97
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2011.245
– volume: 21
  start-page: 884
  issue: 6
  year: 2012
  ident: 9836_CR63
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2010.0576
– volume: 5
  start-page: 205
  issue: 2
  year: 2009
  ident: 9836_CR47
  publication-title: Purinergic Signal
  doi: 10.1007/s11302-009-9139-1
– volume: 234
  start-page: 2095
  issue: 3
  year: 2019
  ident: 9836_CR95
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.27544
– volume: 33
  start-page: 2092
  issue: 12
  year: 2018
  ident: 9836_CR8
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/gfy115
– volume: 24
  start-page: 1235
  issue: 4
  year: 2013
  ident: 9836_CR99
  publication-title: Osteoporos Int
  doi: 10.1007/s00198-012-2059-x
– volume: 276
  start-page: 11135
  issue: 14
  year: 2001
  ident: 9836_CR101
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M010353200
– volume: 21
  start-page: 1725
  issue: 14
  year: 2020
  ident: 9836_CR6
  publication-title: Expert Opin Pharmacother
  doi: 10.1080/14656566.2020.1787381
– volume: 16
  start-page: 846
  issue: 5
  year: 2001
  ident: 9836_CR46
  publication-title: J Bone Miner Res
  doi: 10.1359/jbmr.2001.16.5.846
– volume: 136
  start-page: 3054
  issue: 7
  year: 1995
  ident: 9836_CR26
  publication-title: Endocrinology
  doi: 10.1210/endo.136.7.7789332
– volume: 39
  start-page: 300
  issue: 2
  year: 2006
  ident: 9836_CR66
  publication-title: Bone
  doi: 10.1016/j.bone.2006.02.063
– ident: 9836_CR2
  doi: 10.1016/s1297-9589(01
– volume: 287
  start-page: C403
  issue: 2
  year: 2004
  ident: 9836_CR55
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00361.2003
– volume: 372
  start-page: 486
  issue: 3
  year: 2008
  ident: 9836_CR114
  publication-title: Biochem Biophys Res Commun.
  doi: 10.1016/j.bbrc.2008.05.066
– volume: 117
  start-page: 161
  year: 2018
  ident: 9836_CR18
  publication-title: Bone
  doi: 10.1016/j.bone.2018.09.012
– volume: 272
  start-page: 735
  issue: 5262
  year: 1996
  ident: 9836_CR61
  publication-title: Science
  doi: 10.1126/science.272.5262.735
– volume: 16
  start-page: 437
  issue: 8
  year: 2020
  ident: 9836_CR5
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-020-0341-0
– volume: 302
  start-page: E561
  issue: 5
  year: 2012
  ident: 9836_CR71
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00209.2011
– volume: 24
  start-page: 14316
  issue: 24
  year: 2020
  ident: 9836_CR17
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.16048
– volume: 73
  start-page: 361
  issue: 4
  year: 2003
  ident: 9836_CR53
  publication-title: Calcif Tissue Int
  doi: 10.1007/s00223-002-2098-y
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SecondaryResourceType review_article
Snippet Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The...
Abstract Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary...
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SubjectTerms Biomedical and Life Sciences
Biomedicine
Bone and Bones
Bone growth
Bone resorption
Bone turnover
Cancer Research
Homeostasis
Human Physiology
Humans
Inflammation
Neurosciences
Osteoblasts
Osteoclasts
Osteogenesis
Osteoporosis
Pharmacology/Toxicology
Receptors, Purinergic P2X7
Review
Review Article
Therapeutic targets
Title P2X7Rs: new therapeutic targets for osteoporosis
URI https://link.springer.com/article/10.1007/s11302-021-09836-0
https://www.ncbi.nlm.nih.gov/pubmed/35106736
https://www.proquest.com/docview/2782223486
https://www.proquest.com/docview/2624950198
https://pubmed.ncbi.nlm.nih.gov/PMC9984661
Volume 19
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