P2X7Rs: new therapeutic targets for osteoporosis

• Published in: Purinergic signalling Vol. 19; no. 1; pp. 207 - 219
• Main Authors: Huang, Haoyun, He, Yu-Mei, Lin, Miao-Miao, Wang, Yanchao, Zhang, Xiaomei, Liang, Li, He, Xueling
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.03.2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Bone and Bones; Bone growth; Bone resorption; Bone turnover; Cancer Research; Homeostasis; Human Physiology; Humans; Inflammation; Neurosciences; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Pharmacology/Toxicology; Receptors, Purinergic P2X7; Review; Review Article; Therapeutic targets; Osteoporosis; Osteoclasts; Inflammation; P2X7 receptor; Osteoblasts
• ISSN: 1573-9538; 1573-9546; 1573-9546
• DOI: 10.1007/s11302-021-09836-0

Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.