Health-related quality of life of patients with a recent fracture attending a fracture liaison service: a 3-year follow-up study
Summary This study explored the course of health state utility value over 3 years in patients with a recent fracture attending a Fracture Liaison Service and suggested that the overall change in health-related quality of life was not significant, although significant improvements were observed at 6...
Saved in:
Published in | Osteoporosis international Vol. 33; no. 3; pp. 577 - 588 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Springer London
01.03.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Summary
This study explored the course of health state utility value over 3 years in patients with a recent fracture attending a Fracture Liaison Service and suggested that the overall change in health-related quality of life was not significant, although significant improvements were observed at 6 and 12 months compared to baseline.
Introduction
To estimate the 3-year health-related quality of life (HRQoL) of patients with a recent fracture presenting at a Fracture Liaison Service (FLS) and to explore factors associated with health state utility value (HSUV).
Methods
Patients’ HSUVs were derived from the EQ-5D-5L and SF-6D and calculated at six time points. Multiple imputation was applied for missing data. Linear mixed-effects regression analysis with random intercept and slope was applied to explore the course of HSUV over 3 years. The impact of subsequent fracture and the length of time between FLS visit and patients’ index fracture on HSUV were also investigated. A backward stepwise elimination was applied to identify factors associated with HSUV.
Results
A total of 499 patients were included. The change of EQ-5D HSUV was not significant over 3-year follow-up (
P
= 0.52), although slightly but significantly higher HSUV was captured at 6 months (mean difference (MD): 0.015,
P
= 0.02) and 12 months (MD: 0.018,
P
= 0.01). There was no significant difference in the course of EQ-5D HSUV between fracture locations (
P
= 0.86). A significant increase in HSUV was only captured for patients had shorter time period (< 107 days) between FLS visit and their index fracture. Suffering a subsequent fracture was associated with significant QoL loss (MD: − 0.078,
P
< 0.001). Subsequent fracture, previous treatment with anti-osteoporosis medication, a prevalent vertebral fracture (grade 2 or 3), use of a walking aid, previous falls, and higher BMI were negatively associated with mean EQ-5D HSUV over 3 years. Comparable results were found using SF-6D HSUV. The lack of HRQoL data immediately after fracture and selection bias were two main limitations.
Conclusion
The 3-year change in HSUV was not statistically significant, although significant improvements were observed at 6 and 12 months in comparison with baseline. Six factors were negatively associated with EQ-5D HSUV. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0937-941X 1433-2965 |
DOI: | 10.1007/s00198-021-06204-x |