PhaSepDB: a database of liquid–liquid phase separation related proteins

Abstract It's widely appreciated that liquid–liquid phase separation (LLPS) underlies the formation of membraneless organelles, which function to concentrate proteins and nucleic acids. In the past few decades, major efforts have been devoted to identify the phase separation associated proteins...

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Published inNucleic acids research Vol. 48; no. D1; pp. D354 - D359
Main Authors You, Kaiqiang, Huang, Qi, Yu, Chunyu, Shen, Boyan, Sevilla, Cristoffer, Shi, Minglei, Hermjakob, Henning, Chen, Yang, Li, Tingting
Format Journal Article
LanguageEnglish
Published England Oxford University Press 08.01.2020
Subjects
Database Issue
Databases, Protein
Fluorescence Recovery After Photobleaching
Fluorescent Antibody Technique
Internet
Mass Spectrometry
Organelles - metabolism
Proteins - chemistry
Proteins - metabolism
User-Computer Interface
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Summary:Abstract It's widely appreciated that liquid–liquid phase separation (LLPS) underlies the formation of membraneless organelles, which function to concentrate proteins and nucleic acids. In the past few decades, major efforts have been devoted to identify the phase separation associated proteins and elucidate their functions. To better utilize the knowledge dispersed in published literature, we developed PhaSepDB (http://db.phasep.pro/), a manually curated database of phase separation associated proteins. Currently, PhaSepDB includes 2914 non-redundant proteins localized in different organelles curated from published literature and database. PhaSepDB provides protein summary, publication reference and sequence features of phase separation associated proteins. The sequence features which reflect the LLPS behavior are also available for other human protein candidates. The online database provides a convenient interface for the research community to easily browse, search and download phase separation associated proteins. As a centralized resource, we believe PhaSepDB will facilitate the future study of phase separation.
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The authors wish it to be known that, in their opinion, the first three authors should be regarded as Joint First Authors.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkz847