Functional changes of the lateral pterygoid muscle in patients with temporomandibular disorders: a pilot magnetic resonance images texture study

• Published in: Chinese medical journal Vol. 133; no. 5; pp. 530 - 536
• Main Authors: Liu, Meng-Qi, Zhang, Xing-Wen, Fan, Wen-Ping, He, Shi-Lin, Wang, Yan-Yi, Chen, Zhi-Ye
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer Health 05.03.2020; Wolters Kluwer
• Subjects: Adult; Biomarkers; Female; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Original; Pterygoid Muscles - diagnostic imaging; Pterygoid Muscles - pathology; Pterygoid Muscles - physiopathology; Temporomandibular Joint Disorders - diagnostic imaging; Temporomandibular Joint Disorders - pathology; Temporomandibular Joint Disorders - physiopathology; Young Adult
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/CM9.0000000000000658

Texture features were the intrinsic properties of the human tissues and could efficiently detect the subtle functional changes of involved tissue. The pathologic changes of the lateral pterygoid muscle (LPM) were significantly correlated with the temporomandibular disc displacement. However, the occult functional changes of LPM could not be detected by the naked eye on the medical images. The current study was aimed to evaluate the functional changes of the LPM in the patients with temporomandibular disorders (TMDs) using texture analysis. Twenty-nine patients with TMD were performed with magnetic resonance (MR) imaging on a 3.0T MR scanner, who were consecutively recruited from the TMD clinic of Hainan Hospital of Chinese People's Liberation Army General Hospital from February 2019 to September 2019. The patients were classified into three groups according to the disc displacement: disc without displacement (DWoD), disc displacement with reduction (DDWR) and disc displacement without reduction (DDWoR). The gray-level co-occurrence matrix method was applied with the texture analysis of LPM on the axial T2-weighted imaging. The texture features included angular second moment, contrast, correlation, inverse different moment, and entropy. One-way analysis of variance was used for grouped comparisons and receiver operating characteristics (ROC) curve analysis was applied to evaluate the diagnostic efficacy of the texture parameters. Texture contrast of LPM presented significantly lower in DDWoR (46.30 [35.03, 94.48]) than that in DWoD (123.85 [105.06, 143.23]; test statistic = 23.05; P < 0.001). Texture entropy of LPM showed significant differences among DWoD (7.62 ± 0.33), DDWR (6.76 ± 0.35), and DDWoR (6.46 ± 0.39) (PDWoD-DDWR < 0.001, PDWoD-DDWoR < 0.001, and PDDWR-DDWoR = 0.014). Area under the ROC curve (AUC) demonstrated that texture entropy had an excellent diagnostic accuracy for DWoD-DDWR (AUC = 0.96) and DWoD-DDWoR (AUC = 0.98). The texture contrast and entropy could identify the altered functional status of LPM in patients with TMD and could be considered as the effective imaging biomarker to evaluate the functional changes of LPM in TMD.