Epileptogenic modulation index and synchronization in hypsarrhythmia of West syndrome secondary to perinatal arterial ischemic stroke

• Published in: Clinical neurophysiology Vol. 132; no. 5; pp. 1185 - 1193
• Main Authors: Suzuki, Hiroharu, Otsubo, Hiroshi, Yokota, Nanako, Nishijima, Sakura, Go, Cristina, Carter Snead, O., Ochi, Ayako, Rutka, James T., Moharir, Mahendranath
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2021
• Subjects: Focal epilepsy; Functional connectivity; Modulation index; Phase-amplitude coupling; Synchronization likelihood; West syndrome; Functional connectivity; Focal epilepsy; HFOs; Qu; MRI; EEG; West syndrome; Modulation index; Phase-amplitude coupling; PAIS-MCA; Synchronization likelihood; SL; MI; WS; PAIS
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2020.12.028

•Epileptic cortical-subcortical-transcallosal network generates hypsarrhythmia.•Modulation index unveil epileptogenesis of stroke hemisphere in epileptic/infantile spasms of West syndrome.•Brains of West syndrome have stronger epileptic connectivity than Focal epilepsy. Perinatal arterial ischemic stroke (PAIS) is associated with epileptic spasms of West syndrome (WS) and long term Focal epilepsy (FE). The mechanism of epileptogenic network generation causing hypsarrhythmia of WS is unknown. We hypothesized that Modulation index (MI) [strength of phase-amplitude coupling] and Synchronization likelihood (SL) [degree of connectivity] could interrogate the epileptogenic network in hypsarrhythmia of WS secondary to PAIS. We analyzed interictal scalp electroencephalography (EEG) in 10 WS and 11 FE patients with unilateral PAIS. MI between gamma (30–70 Hz) and slow waves (3–4 Hz) was calculated to measure phase-amplitude coupling. SL between electrode pairs was analyzed in 9-frequency bands (5-delta, theta, alpha, beta, gamma) to examine inter- and intra-hemispheric connectivity. MI was higher in affected hemispheres in WS (p = 0.006); no differences observed in FE. Inter-hemispheric SL of 3-delta, theta, alpha, beta, gamma bands was significantly higher in WS (p < 0.001). In WS, modified Z-Score of intra-hemispheric SL values in 3-delta, theta, alpha, beta and gamma in the affected hemispheres were significantly higher than those in the unaffected hemispheres (p < 0.001) as well as 0.5–4 Hz (p = 0.004). The significantly higher modulation in affected hemisphere and stronger inter- and intra-hemispheric connectivity generate hypsarrhythmia of WS secondary to PAIS. Epileptogenic cortical-subcortical transcallosal networks from affected hemisphere post-PAIS provokes infantile spasms.