Long coiled-coil proteins and membrane traffic

Protein transport between organelles is mediated by vesicles which must accurately dock and fuse with appropriate compartments. Over the past several years a large number of long coiled-coil proteins have been identified on the Golgi and on endosomes, mostly as auto-antigens in autoimmune disorders....

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Published inBBA - Molecular Cell Research Vol. 1641; no. 2; pp. 71 - 85
Main Authors Gillingham, Alison K, Munro, Sean
Format Book Review Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 18.08.2003
Subjects
Animals
Cell Membrane - physiology
Coiled-coil
Endoplasmic Reticulum - physiology
Endosome
Endosomes - physiology
Golgi
Golgi Apparatus - physiology
Golgin
Humans
Membrane Transport Proteins - physiology
Protein Transport
Rab GTPase
Vesicle tethering
Coiled-coil
Rab GTPase
Golgi
Vesicle tethering
Endosome
Golgin
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Summary:Protein transport between organelles is mediated by vesicles which must accurately dock and fuse with appropriate compartments. Over the past several years a large number of long coiled-coil proteins have been identified on the Golgi and on endosomes, mostly as auto-antigens in autoimmune disorders. Based on their restricted intracellular distributions and their predicted rod-like structure, these proteins have been proposed to play a role in tethering vesicles to target organelles prior to fusion. However, such proteins may also play a structural role, for example as components of a Golgi matrix, or as scaffolds for the assembly of other factors important for fusion. This review will examine what is known about the function of these large coiled-coil proteins in membrane traffic.
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ISSN:0167-4889
0006-3002
1879-2596
DOI:10.1016/S0167-4889(03)00088-0