Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23

Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic analysis of 1345 GBS isolates from neonatal (age 0–89 days) invasive infections in the...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 10; no. 1; p. 9539
Main Authors Jamrozy, Dorota, Bijlsma, Merijn W., de Goffau, Marcus C., van de Beek, Diederik, Kuijpers, Taco W., Parkhill, Julian, van der Ende, Arie, Bentley, Stephen D.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.06.2020
Nature Publishing Group
Subjects
45/23
631/326/325/1506
631/326/421
Bacterial Proteins - genetics
Cell surface
Cloning
DNA, Bacterial - genetics
Female
Genomic analysis
Genomics - methods
Humanities and Social Sciences
Humans
Incidence
Infant
Infant, Newborn
Infections
Male
multidisciplinary
Multilocus Sequence Typing
Neonates
Netherlands
Phages
Phylogenetics
Phylogeny
Science
Science (multidisciplinary)
Serogroup
Streptococcal Infections - microbiology
Streptococcus
Streptococcus - genetics
Streptococcus infections
Netherlands
Online AccessGet full text

Cover

More Information
Summary:Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic analysis of 1345 GBS isolates from neonatal (age 0–89 days) invasive infections in the Netherlands reported between 1987 and 2016. Most isolates clustered into one of five major lineages: CC17 (39%), CC19 (25%), CC23 (18%), CC10 (9%) and CC1 (7%). There was a significant rise in the number of infections due to isolates from CC17 and CC23. Phylogenetic clustering analysis revealed that this was caused by expansion of specific sub-lineages, designated CC17-A1, CC17-A2 and CC23-A1. Dating of phylogenetic trees estimated that these clones diverged in the 1960s/1970s, representing historical rather than recently emerged clones. For CC17-A1 the expansion correlated with acquisition of a new phage, carrying gene encoding a putative cell-surface protein. Representatives of CC17-A1, CC17-A2 and CC23-A1 clones were identified in datasets from other countries demonstrating their global distribution.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-66214-3